雾化吸入布地奈德联合地塞米松静脉注射治疗早产儿支气管肺发育不良的疗效观察

Effect of nebulized inhalation of budesonide combined with intravenous injection of dexamethasone in the treatment of preterm infants with bronchopulmonary dysplasia

目的探讨雾化吸入布地奈德联合地塞米松静脉注射治疗早产儿支气管肺发育不良(BPD)的疗效及安全性。方法将130例BPD早产儿随机分为对照组(n=65)和试验组(n=65)。对照组在常规治疗的基础上给予醋酸地塞米松注射液治疗,试验组在对照组基础上给予雾化吸入布地奈德混悬液治疗,2组均连续治疗10 d。比较2组早产儿的吸氧时间、机械通气时间、住院时间、临床疗效和不良反应情况,并在矫正胎龄36周时或出院时对2组早产儿进行BPD分度比较。结果治疗后,试验组的吸氧时间、机械通气时间和住院时间均短于对照组;试验组BPD分度优于对照组;试验组临床总有效率为89.23%,高于对照组的69.23%;上述组间差异均有统计学意义(P<0.05)。2组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论雾化吸入布地奈德联合地塞米松静脉注射治疗早产儿BPD安全有效,可显著缩短吸氧时间、机械通气时间和住院时间,改善病情分度。

Objective To investigate the efficacy and safety of nebulized inhalation of budesonide combined with intravenous injection of dexamethasone in the treatment of preterm infants with bronchopulmonary dysplasia(BPD).Methods A total of 130 preterm infants with BPD were randomly divided into control group(n=65)and experimental group(n=65).The control group received dexamethasone acetate injection on the basis of conventional treatment,while the experimental group was treated with nebulized inhalation of budesonide suspension on the basis of the control group,and both groups were treated continuously for 10 days.The oxygen inhalation time,mechanical ventilation time,hospitalization time,clinical efficacy,and adverse reactions were compared between the two groups,and the BPD grading was also compared between the two groups at 36 weeks of corrected gestational age or at discharge.Results After treatment,the oxygen inhalation time,mechanical ventilation time,and hospitalization time in theexperimental group were shorter than those in the control group;the BPD grading in the experimental group was better than that in the control group;the clinical total effective rate in the experimental group was 89.23%,which was higher than 69.23%in the control group;all the between-group differences mentioned above were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Nebulized inhalation of budesonide combined with intravenous injection of dexamethasone is safe and effective in treating preterm infants with BPD,which can significantly shorten oxygen inhalation time,mechanical ventilation time and hospitalization time,and improve disease grading.