温针灸治疗肿瘤化疗相关性周围神经病变的有效性和安全性

Efficacy and Safety of Warming Needle Moxibustion in the Treatment of Chemotherapy-induced Peripheral Neuropathy

目的:探究温针灸治疗肿瘤化疗相关性周围神经病变(CIPN)的有效性和安全性。方法:采用随机数字表法将2020年7月—2022年8月南昌市人民医院收治的乳腺癌CIPN患者100例分为两组,各50例。对照组采用温针灸治疗,试验组采用针刺治疗,均治疗2个疗程。对比两组有效性和安全性、卡式(KPS)评分、生活质量评分。结果:试验组总有效率为94.00%,高于对照组的76.00%,差异有统计学意义(P<0.05)。相比于对照组,试验组治疗后KPS评分高,差异有统计学意义(P<0.05);治疗后,两组KPS评分均高于治疗前,差异均有统计学意义(P<0.05)。相比于对照组,试验组治疗后生活质量各项评分均高,差异均有统计学意义(P<0.05);治疗后两组社会功能、躯体功能、认知功能、情绪功能、角色功能评分均高于治疗前,差异均有统计学意义(P<0.05)。相比于对照组,试验组神经毒性较轻,差异有统计学意义(P<0.05)。结论:温针灸在乳腺癌CIPN患者治疗中获得理想效果,能够有效改善患者功能状态,并可提升患者生活质量,减轻化疗药物的神经毒性。

Objective:To explore the efficacy and safety of warming needle moxibustion in the treatment of chemotherapy-induced peripheral neuropathy(CIPN).Method:A total of 100 patients with breast cancer CIPN admitted to Nanchang People's Hospital from July 2020 to August 2022 were divided into two groups by random number table method,with 50 cases in each group.The control group was treated with warming needle moxibustion,and the experimental group was treated with acupuncture,both of which were treated for 2 courses.Efficacy and safety,KPS score and quality of life score were compared between the two groups.Result:The total effective rate of experimental group was 94.00%,which was higher than 76.00% of control group,the difference was statistically significant(P<0.05).Compared with control group,KPS score of experimental group after treatment was higher,the difference was statistically significant(P<0.05).After treatment,KPS scores in both groups were higher than those before treatment,the differences were statistically significant(P<0.05).Compared with control group,each item scores of quality of life in experimental groups after treatment were higher,the differences were statistically significant(P<0.05).After treatment,the scores of social function,physical function,cognitive function,emotional function and role function of the two groups were higher than those before treatment,the differences were statistically significant(P<0.05).Compared with the control group,the neurotoxicity of experimental group was less,the difference was statistically significant(P<0.05).Conclusion:Acupuncture has achieved ideal results in the treatment of patients with breast cancer CIPN,which can effectively improve the functional status of patients,improve the quality of life of patients,and reduce the neurotoxicity of chemotherapy drugs.