抗VEGF玻璃体腔注射+视网膜激光光凝术对早产儿视网膜病变屈光参数及晶状体参数的影响

Effects of Anti-VEGF Intravitreal Injection Plus Retinal Laser Photocoagulation on Refractive Parameters and Lens Parameters of Retinopathy of Prematurity

目的:探究抗血管内皮生长因子(VEGF)玻璃体腔注射+视网膜激光光凝术治疗对早产儿视网膜病变(ROP)患儿屈光参数及晶状体参数的影响。方法:选取2020年1月—2023年1月福建省南平市第一医院眼科收治的120例ROP患儿,随机分为A组(n=60)与B组(n=60)。B组行视网膜激光光凝术治疗,A组予以抗VEGF玻璃体腔注射+视网膜激光光凝术治疗。比较两组临床效果、房水血管相关因子[血小板衍生生长因子(PDGF)、转化生长因子-β1(TGF-β1)、VEGF]水平、屈光参数及晶状体参数(前房深度、晶状体厚度、玻璃体腔长度、眼轴长度)及治疗期间并发症发生情况。结果:术后6个月,A组临床总有效率(92.92%)较B组(80.53%)高,差异有统计学意义(P<0.05)。术后6个月,A组PDGF、TGF-β1、VEGF水平均较B组低,差异均有统计学意义(P<0.05)。术后6个月,A组前房深度较B组深,玻璃体腔长度、眼轴长度较B组长,晶状体厚度较B组薄,差异均有统计学意义(P<0.05)。A组并发症发生率(1.77%)较B组(9.73%)低,差异有统计学意义(P<0.05)。结论:抗VEGF玻璃体腔注射+视网膜激光光凝术治疗ROP患儿临床效果显著,可改善患儿房水血管相关因子水平、屈光参数及晶状体参数,安全性高。

Objective:To investigate the effects of intravitreal injection of anti-vascular endothelial growth factor(VEGF)plus retinal laser photocoagulation on refractive parameters and lens parameters in children with retinopathy of prematurity(ROP).Method:A total of 120 children with ROP admitted to the Ophthalmology Department of Nanping First Hospital of Fujian Province from January 2020 to January 2023 were selected,and were randomly divided into group A(n=60)and group B(n=60).Group B was treated with retinal laser photocoagulation,group A was treated with anti-VEGF intravitreal intravitreal injection plus retinal laser photocoagulation.The clinical efficacy,the levels of aqueous vascular factors[platelet-derived growth factor(PDGF),transforming growth factor-β1(TGF-β1),VEGF],refractive parameters and lens parameters(anterior chamber depth,lens thickness,vitreal length,axial length)and the occurrence of complications duration of treatment were compared between the two groups.Result:Six months after operation,the clinical effect of group A(92.92%)was higher than that of group B(80.53%),the difference was statistically significant(P<0.05).6 months after surgery,the levels of PDGF,TGF-β1 and VEGF in group A were lower than those in group B,the differences were statistically significant(P<0.05).6 months after surgery,the anterior chamber depth in group A was deeper than that in group B,vitreous cavity length and ocular axis length were longer than those in group B,and the lens thickness was thinner than that in group B,the differences were statistically significant(P<0.05).The complication rate of group A(1.77%)was lower than that of group B(9.73%),the difference was statistically significant(P<0.05).Conclusion:Anti-VEGF intravitreal injection plus retinal laser photocoagulation is effective in the treatment of children with ROP,which can improve the level of water-vascularity-related factors,refractive parameters and lens parameters in children with high safety.