儿童慢性咳喘经电子支气管镜行支气管肺泡灌洗的效果分析

Effect Analysis of Bronchoalveolar Lavage by Electronic Bronchoscope in Children with Chronic Cough and Asthma

目的:探讨儿童慢性咳喘经电子支气管镜行支气管肺泡灌洗的效果。方法:选取2021年5月—2023年10月于宜春市妇幼保健院在常规治疗基础上经电子支气管镜行支气管肺泡灌洗的66例慢性咳喘患儿作为治疗组,另选取2020年1月—2021年4月于本院接受常规治疗的46例慢性咳喘患儿作为对照组。比较两组治疗效果、炎症因子指标、预后转归状况、血气指标等。结果:治疗组总有效率为93.94%,高于对照组的54.35%,差异有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-17(IL-17)、白细胞介素-5(IL-5)、二氧化碳分压(PaCO_(2))均低于治疗前,血氧饱和度(SaO_(2))、氧分压(PaO_(2))均高于治疗前,且治疗组TNF-α、CRP、PCT、IL-17、IL-5、PaCO_(2)均低于对照组,SaO_(2)、PaO_(2)均高于对照组,差异均有统计学意义(P<0.05)。治疗组再住院率为4.55%,低于对照组的26.09%,差异有统计学意义(P<0.05)。治疗组症状消失时间早于对照组,住院时间短于对照组,差异均有统计学意义(P<0.05)。结论:经电子支气管镜行支气管肺泡灌洗治疗儿童慢性咳喘,能更好地缓解机体炎症反应,调节血气指标,改善疾病预后和转归,疗效理想。

Objective:To investigate the effect of bronchoalveolar lavage by electronic bronchoscope in children with chronic cough and asthma.Method:A total of 66 children with chronic cough and asthma who underwent bronchoalveolar lavage by electronic bronchoscope on the basis of the routine treatment in Yichun Maternal and Child Health Hospital from May 2021 to October 2023 were selected as the treatment group,and 46 children with chronic cough and asthma who received routine treatment in outhor's hospital from January 2020 to April 2021 were selected as the control group.The therapeutic effect,inflammatory factors,prognosis,blood gas and so on between the two groups were compared.Result:The total effective rate of the treatment group was 93.94%,which was higher than 54.35% of the control group,the difference was statistically significant(P<0.05).After treatment,tumor necrosis factor-α(TNF-α),C reactive protein(CRP),procalcitonin(PCT),interleukin-17(IL-17),interleukin-5(IL-5)and partial pressure of carbon dioxide(PaCO_(2))were lower than those before treatment,and blood oxygen saturation(SaO_(2)),oxygen partial pressure(PaO_(2))were higher than those before treatment,and TNF-α,CRP,PCT,IL-17,IL-5 and PaCO_(2)in treatment group were lower than those in control group,and SaO_(2),PaO_(2)were higher than those in control group,the differences were statistically significant(P<0.05).The rate of rehospitalization in the treatment group was 4.55%,which was lower than 26.09%in the control group,the difference was statistically significant(P<0.05).The time of symptom disappearance in the treatment group was earlier than that in the control group,and hospital stay in the treatment group was shorter than that in the control group,the differences were statistically significant(P<0.05).Conclusion:Bronchoalveolar lavage by electronic bronchoscope in the treatment of chronic cough and asthma in children can better relieve inflammation,regulate blood gas index,improve disease prognosis and outcome,and the curative effect is ideal.