多切面连续超声联合血清三联生化标志物在筛查胎儿畸形中的应用价值

Application Value of Multi Section Continuous Ultrasound Combined with Serum Triple Biochemical Markers in Screening Fetal Malformations

目的探讨多切面连续超声联合血清三联生化标志物在筛查胎儿畸形中的应用价值。方法选取2019年1月—2021年12月在阳江高新技术产业开发区平冈镇中心卫生院进行产前筛查查出疑似胎儿畸形的孕中期孕妇60例为研究对象,进行超声检查以及血清三联检查,以尸检以及妊娠结果作为金标准,比较超声组、血清组以及超声联合血清组的阴性、阳性的结果、诊断效能以及检查结果。结果超声联合血清组的阳性率高于其他两组,差异有统计学意义(P<0.05);超声联合血清的准确性、灵敏度、特异度、阳性预测值以及阴性预测值均高于其他两组,差异有统计学意义(P<0.05);符合金标准的为60例(100.00%),超声联合血清组的总查出率96.67%,显著高于超声组(68.33%)和血清组(83.33%),差异有统计学意义(P<0.05)。结论多切面连续超声联合血清三联生化标志物在筛查胎儿畸形中具有较高的准确率,适合广泛推广。

Objective To explore application value of multi section continuous ultrasound combined with serum triple biochemical markers in screening fetal malformations.Methods The paper chose 60 mid pregnancy pregnant women with suspected fetal malformations treated with prenatal screening in Yangjiang High tech Industrial Development Zone Pinggang Town Central Health Center from January 2019 to December 2021 as study subjects.Negative and positive results,diagnostic effect,and examination results of ultrasound group,serum group,ultrasound combined with serum group were compared with gold standard of autopsy and pregnancy results after ultrasound examination and serum triple detection.Results Positive rate of ultrasound combined with serum group was higher than the other two groups,difference was statistically significant(P<0.05).Accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of ultrasound combined with serum was higher than the other two groups,difference was statistically significant(P<0.05).Detection rate of gold standard was 60%(100.00%),and total detection rate of ultrasound combined with serum group was 95.00%,with statistically significant difference(P<0.05).Conclusion Multi section continuous ultrasound combined with serum triple biochemical markers screening can achieve relatively high accuracy for fetal malformations,which is suitable for wide promotion.