胺碘酮与普罗帕酮治疗心律失常的临床效果及安全性对比分析

Comparative Analysis of Clinical Effect and Safety Between Amiodarone and Propafenone in Treatment of Arrhythmia

目的探讨胺碘酮与普罗帕酮治疗心律失常的临床效果及安全性对比分析。方法将2022年1—12月在本院治疗的94例心律失常患者随机分为两组,对照组(47例)使用普罗帕酮治疗,观察组(47例)使用胺碘酮治疗,对比两组的临床疗效、心肌损伤标志物、心功能及CRP水平、不良反应。结果治疗有效率组间统计学结果显示,观察组明显更高,组间差异有统计学意义(P<0.05);观察组治疗后CK-MB、cTnI、BNP水平均低于对照组,组间差异有统计学意义(P<0.05);观察组治疗后LVEF明显高于对照组,HR、SBP、CRP均低于对照组,组间差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,组间差异有统计学意义(P<0.05)。结论胺碘酮治疗心律失常的临床效果及安全性更好,能有效改善心功能,减少心肌损伤,降低炎症反应程度,具有积极的临床意义。

Objective To explore clinical effect and safety comparison analysis of amiodarone and propafenone in treatment of arrhythmia.Methods The paper chose 94 patients with arrhythmia in our hospital from January 2022 to December 2022,and divided them into two groups randomly.Control group was treated with propafenone,while observation group with amiodarone.Clinical effect,myocardial injury markers,heart function,CRP levels,and adverse reactions were compared between two groups.Results Statistical data showed,treatment effective rate in observation group was significantly higher(P<0.05).After treatment,levels of CK MB,cTnI,and BNP in observation group were lower than control group(P<0.05).After treatment,LVEF in observation group was significantly higher than control group,while HR,SBP,and CRP was lower than control group(P<0.05).Incidence of adverse reactions in observation group was lower than control group(P<0.05).Conclusion Amiodarone can achieve good clinical effect and safety in treatment of arrhythmia,can improve heart function,reduce myocardial injury,and lower degree of inflammatory response effectively,which has positive clinical significance.