糖尿病肾病患者血清NT-proBNP、PCT、β2-MG变化及意义

Changes and Significance of Serum NT-proBNP,PCT,β2-MG of Patients with Diabetes Nephropathy

目的探究糖尿病肾病(DN)患者血清氨基末端脑钠肽前体(NT-proBNP)、降钙素原(PCT)、β2微球蛋白(β2-MG)变化及意义。方法选取2020年10月—2022年10月本院收治的213例DN患者纳入DN组,糖尿病非肾病患者100例作为非DN组,DN组根据病情分期进一步分为Ⅰ期组(n=102)、Ⅱ期组(n=65)、Ⅲ期组(n=46)。比较DN组、非DN组肾功能指标[血肌酐(Scr)、尿白蛋白排泄率(UAER)]及血清NT-proBNP、PCT、β2-MG水平,以及Ⅰ期组、Ⅱ期组、Ⅲ期组血清NT-proBNP、PCT、β2-MG水平,采用Pearson相关性分析血清NT-proBNP、PCT、β2-MG与Scr、UAER的相关性。结果DN组Scr、UAER及血清NT-proBNP、PCT、β2-MG水平均高于非DN组(P<0.05);Ⅰ期组、Ⅱ期组、Ⅲ期组血清NT-proBNP、PCT、β2-MG水平均依次升高(P<0.05),且组间差异均有统计学意义(P<0.05);Pearson相关性分析显示,血清NT-proBNP、PCT、β2-MG与Scr、UAER均呈正相关性(P<0.05)。结论DN患者血清NT-proBNP、PCT、β2-MG表达上调,且其水平与病情程度有关。

Objective To explore changes and significance of serum N-terminal pro brain natriuretic peptide(NT proBNP),procalcitonin(PCT),β2-Microglobulin(β2-MG)of patients with diabetes nephropathy.Methods The paper chose 213 DN patients in our hospital from October 2020 to October 2022 as DN group,and 100 patients with diabetes and non kidney disease as non DN group,and further divided DN group into phase I group(n=102),phaseⅡgroup(n=65),and phaseⅢgroup(n=46)according to disease stage.Renal function indicators of serum creatinine(Scr),urinary albumin excretion rate(UAER),and serum NT proBNP,PCT,β2-MG levels were compared between DN and non DN groups,serum NT proBNP,PCT,β2-MG levels were compared between phase I,Ⅱ,Ⅲgroups.Correlation betweenβ2-MG,Scr and UAER was analyzed with Pearson correlation analysis.Results Scr,UAER and serum NT proBNP,PCT,β2-MG levels in DN group were higher than non DN group(P<0.05).Serum NT proBNP,PCT,β2-MG levels increased sequentiall y in phase I,Ⅱ,Ⅲgroup,(P<0.05),and there was statistically significant difference between groups(P<0.05).Pearson correlation analysis showed serum NT proBNP,PCTβ2-MG was positively correlated with Scr and UAER(P<0.05).Conclusion Serum NT proBNP,PCT,β2-MG expression is upregulated,whose level is related to severity of the disease.