参松养心胶囊和琥珀酸美托洛尔缓释片联合治疗室性早搏的有效性与安全分析

Efficacy and Safety Analysis of Shensong Yangxin Capsules Combined with Metoprolol Succinate Sustained-release Tablets in the Treatment of Premature Ventricular Beats

目的:探究参松养心胶囊联合琥珀酸美托洛尔缓释片治疗室性早搏(PVB)的有效性与安全性。方法:选择萍乡市第二人民医院2021年10月—2023年10月收治的PVB患者74例,按随机数字表法分为两组,各37例。对照组予以琥珀酸美托洛尔缓释片治疗,在对照组的基础上,观察组予以参松养心胶囊。对比两组临床效果、症候积分、炎症因子、心功能指标、不良反应发生情况。结果:相较对照组,观察组治疗总有效率高,差异有统计学意义(P<0.05)。治疗后,观察组各项症候积分、C反应蛋白(CRP)、白细胞介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)均较对照组低,左室射血分数(LVEF)较对照组高,差异均有统计学意义(P<0.05)。两组不良反应发生率分别为13.51%、8.11%,差异无统计学意义(P>0.05)。结论:在PVB患者中使用参松养心胶囊联合琥珀酸美托洛尔缓释片治疗,可提高临床效果,加快临床相关症状缓解,改善心功能,减轻炎症反应,且安全可靠。

Objective:To explore the efficacy and safety of Shensong Yangxin Capsules combined with Metoprolol Succinate Sustained-release Tablets in the treatment of premature ventricular beats(PVB).Method:A total of 74 patients with PVB treated in the Pingxiang NO.2 People's Hospital from October 2021 to October 2023 were divided into two groups by random number table method,with 37 cases in each group.The control group was treated with Metoprolol Succinate Sustained-release Tablets,and the observation group was treated with Shensong Yangxin Capsules on the basis of the control group.The clinical effects,symptom scores,inflammatory factors,cardiac function indexes and incidence of adverse reactions were compared between the two groups.Result:Compared with the control group,the total effective rate of the observation group was higher,the difference was statistically significant(P<0.05).After treatment,the symptom scores,C reactive protein(CRP),interleukin-6(IL-6),matrix metalloproteinase-9(MMP-9),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)in the observation group were lower than those in the control group,the left ventricular ejection fraction(LVEF)was higher than that of the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the two groups was 13.51% and 8.11%,respectively,the difference was not statistically significant(P>0.05).Conclusion:The combination of Shensong Yangxin Capsules and Metoprolol Succinate Sustained-release Tablets in the treatment of PVB has good clinical effect,can accelerate the remission of clinical symptoms,improve cardiac function,reduce inflammation reactions,and is safe and reliable.