阿芬太尼复合丙泊酚对老年无痛胃镜检查患者的麻醉效果及其安全性探究

The Aesthetic Effect and Safety of Alfentannil Compound Propofol in Elderly Patients with Painless Gastroscopy Examination

目的:探究阿芬太尼复合丙泊酚应用于老年患者无痛胃镜检查中的临床疗效和安全性。方法:选取2022年1月—2023年7月在宜春学院第二附属医院进行无痛胃镜检查的80例老年患者为研究对象,随机分为研究组(n=40)和对照组(n=40)。研究组实施阿芬太尼复合丙泊酚的麻醉方式,对照组实施芬太尼复合丙泊酚的麻醉方式。对比两组患者麻醉效果及安全性。结果:研究组仅在进镜至十二指肠(T_(3))时的平均动脉压(MAP)与给药前(T_(1))时比较,差异有统计学意义(P<0.05),而对照组在进镜至咽喉(T_(2))、T_(3)、检查结束(T_(4))的MAP、心率(HR)与T_(1)时比较,差异均有统计学意义(P<0.05);T_(2)及T_(3)时研究组的MAP与HR均高于对照组,差异均有统计学意义(P<0.05)。两组丙泊酚泵注时间及操作时间对比,差异均无统计学意义(P>0.05),研究组丙泊酚总用量多于对照组,研究组的苏醒时间长于对照组,差异均有统计学意义(P<0.05)。研究组的不良反应发生率(7.50%)低于对照组(25.00%),差异有统计学意义(P<0.05)。结论:阿芬太尼与丙泊酚联用能保持生命体征平稳,降低患者的不良反应,提高患者的安全性,但由于需额外输入丙泊酚,延长了患者的苏醒时间。

Objective:To investigate the clinical efficacy and safety of Alfentanil combined with Propofol in painless gastroscopy examination in elderly patients.Method:A total of 80 elderly patients who underwent painless gastroscopy examination at the Second Affiliated Hospital of Yichun University,from January 2022 to July 2023 were selected for the study,and were randomly divided into the study group(n=40)and control group(n=40).The anaesthesia of Alfentanil combined with Propofol was implemented in the study group,and the anaesthesia of Fentanyl combined with Propofol was implemented in the control group.The anaesthetic effect and safety of the two groups were compared.Result:The mean arterial pressure(MAP)of the study group only at the time of entry to the duodenum(T_(3))was compared with that at the time before drug administration(T_(1)),the difference was statistically significant(P<0.05);while the MAP and heart rate(HR)of the control group at the time of entry to the pharynx(T_(2)),T_(3),and the end of the examination(T_(4))were compared with those at the time of T_(1),the differences were statistically significant(P<0.05);the MAP and HR of the study group at T_(2) and T_(3) were higher than those of the control group,the differences were statistically significant(P<0.05).Comparison of Propofol pumping time and operation time between the two groups,the differences were not statistically significant(P>0.05);the total dosage of Propofol in the study group was more than that in the control group,and the awakening time in the study group was longer than that in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions was lower in the study group(7.50%)than that in the control group(25.00%),the difference was statistically significant(P<0.05).Conclusion:The combination of Afentanil and Propofol can keep the vital signs stable,reduce the adverse reactions of patients,and improve the safety of patients,but because of the need for additional Propofol,the recovery time of patients is prolonged.