右佐匹克隆联合艾司唑仑对脑卒中后睡眠障碍患者的临床效果观察

Observation on the Clinical Effect of Dexzopiclone Combined with Estazolam on Patients with Sleep Disorders after Stroke

目的:探讨艾司唑仑与右佐匹克隆联合治疗对脑卒中后发生睡眠障碍患者的临床效果。方法:选取武汉市第九医院神经内科2022年3月—2023年3月收治的脑卒中后睡眠障碍的患者100例,随机将其分为对照组50例和研究组50例。对照组服用艾司唑仑片治疗,研究组服用艾司唑仑片和右佐匹克隆片治疗。观察对比治疗前后两组的睡眠质量和神经功能情况,对比治疗后两组的治疗效果和不良反应发生情况。结果:治疗后,研究组匹兹堡睡眠质量指数(PSQI)评分和改良爱丁堡-斯堪的那维亚量表(MESSS)评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组治疗总有效率(94.00%)高于对照组(74.00%),差异有统计学意义(P<0.05)。治疗后,研究组不良反应发生率(18.00%)与对照组(12.00%)比较,差异无统计学意义(P>0.05)。结论:右佐匹克隆联合艾司唑仑治疗脑卒中后睡眠障碍能够有效提高患者的睡眠质量,改善患者的神经功能情况,提高患者的治疗效果,安全可行。

Objective:To explore the clinical effect of the combined treatment of Estazolam and Dexzopiclone on patients with sleep disorders after stroke.Method:A total of one hundred patients with sleep disorders after stroke admitted to the Neurology Department of Wuhan Ninth Hospital from March 2022 to March 2023 were selected,and they were randomly divided into a control group of 50 cases and a study group of 50 cases.The control group was treated with Estazolam Tablets,and the study group was treated with Estazolam Tablets and Dexzopiclone Tablets.The sleep quality and neurological function of the two groups before and after treatment were observed and compared,and the therapeutic effect and the occurrence of adverse reactions of the two groups after treatment were compared.Result:After treatment,the scores of Pittsburgh sleep quality index(PSQI)and modified Edinburgh-Scandinavian stroke scale(MESSS)in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the total effective rate of treatment in the study group(94.00%)was higher than that in the control group(74.00%),the difference was statistically significant(P<0.05).After treatment,the incidence of adverse reactions in the study group(18.00%)compared to the control group(12.00%),the difference was not statistically significant(P>0.05).Conclusion:The combination of Dexzopiclone and Estazolam in the treatment of sleep disorders after stroke can effectively improve the sleep quality of patients,improve their neurological function,enhance their treatment efficacy,and is safe and feasible.