药源性心脏毒性模型的构建与评价进展

Progress in construction and evaluation of a drug-induced cardiotoxicity model

目的了解药源性心脏毒性动物模型的建立与应用,为药源性心脏毒性的防治提供研究基础。方法采用文献研究,以“心脏毒性”和“cardiotoxicity”等为主题词,在中国知网和Web of science core collection数据库选取2015年1月1日至2024年4月4日应用药源性心脏毒性模型的相关文献,按照纳入标准筛选出应用药源性心脏毒性动物模型的实验研究文献,并使用分析软件Citespace 6.3R1(64-bit)Basic结合Excel对纳入文献进行可视化呈现。结果共纳入731篇文献。应用于药源性心脏毒性研究的模式动物多选用大鼠、小鼠、斑马鱼,造模剂以阿霉素、乌头碱、布比卡因为主,毒性机制涉及氧化应激、细胞凋亡等。大多采用一般指标、组织病理指标、心脏功能检测指标等多类别指标变化进行综合评价。其应用也较为集中,评价药源性心脏毒性模型的标准存在较大差异。结论目前药源性心脏毒性模型的研究仍具有一定的发展前景,为系统开展中医药防治药源性心脏毒性提供依据。

Objective To find out about the establishment and applications of animal models for drug-induced cardiotoxicity,and to provide data for the prevention and treatment of drug-induced cardiotoxicity.Methods Literature research was conducted using“cardiotoxicity”as the key term.Related literature on applications of drug-induced cardiotoxicity models published since 2015 was selected from the CNKI and Web of Science Core Collection databases.Literature about experimental research on applications of animal models for drug-induced cardiotoxicity was screened based on the inclusion criteria.Analysis software Citespace 6.3 R1(64-bit)Basic as well as Excel was used to visualize the selected literature.Results A total of 731 articles were included.The model animals used in studies of drug-induced cardiotoxicity were mostly rats,mice and zebrafish while the modeling agents were chiefly adriamycin,aconitine and bupivacaine.The toxicity mechanism involved oxidative stress and apoptosis.Most studies used such multi-category indicators as general indicators,histopathological indicators,and cardiac function test indicators for comprehensive evaluation.The applications were also relatively concentrated,and there were great differences in the criteria for evaluating drug-induced cardiotoxicity models.Conclusion Research on drug-induced cardiotoxicity models remains promising,which can facilitate systematic development of Traditional Chinese Medicine for the prevention and treatment of drug-induced cardiotoxicity.