双歧杆菌四联活菌片联合胰岛素泵治疗妊娠期糖尿病患者的效果

Effects of Bifidobacterium quadruple viable tablets combined with insulin pump in treatment of patients with gestational diabetes mellitus

目的:观察双歧杆菌四联活菌片联合胰岛素泵治疗妊娠期糖尿病患者的效果。方法:选取2021年9月至2023年9月南阳陇海医院收治的89例妊娠期糖尿病患者进行前瞻性研究,按照随机数字表法将其分为对照组44例和观察组45例。对照组采用胰岛素泵治疗,观察组在对照组基础上联合双歧杆菌四联活菌片治疗,两组均治疗1个月。比较两组治疗前后血糖指标[空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)]、胰岛功能指标[空腹胰岛素(FINS)、胰岛β细胞功能指数(HOMA-β)、胰岛素敏感指数(ISI)、胰岛素抵抗指数(HOMA-IR)]、氧化应激指标[总抗氧化能力(T-AOC)、丙二醛(MDA)、超氧化物歧化酶(SOD)]水平,不良反应发生率,以及不良妊娠结局发生率。结果:治疗后,观察组HbA1c、2hPG、FPG水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组FINS、HOMA-IR水平低于对照组,HOMA-β、ISI水平高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组MDA水平低于对照组,T-AOC、SOD水平高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组不良妊娠结局发生率为11.11%(5/45),低于对照组的29.55%(13/44),差异有统计学意义(P<0.05)。结论:双歧杆菌四联活菌片联合胰岛素泵治疗妊娠期糖尿病患者可降低血糖指标水平和不良妊娠结局发生率,改善胰岛功能指标和氧化应激指标水平,效果优于单纯胰岛素泵治疗。

Objective:To observe effects of Bifidobacterium quadruple viable tablets combined with insulin pump in treatment of patients with gestational diabetes mellitus.Methods:A prospective study was conducted on 89 patients with gestational diabetes mellitus admitted to Nanyang Longhai hospital from September 2021 to September 2023.According to the random number table method,they were divided into control group(44 cases)and observation group(45 cases).The control group was treated with insulin pump,while the observation group was treated with Bifidobacterium quadruple viable tablets on the basis of the control group.Both groups were treated for 1 month.The levels of blood glucose indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],islet function indexes[fasting insulin(FINS),isletβcell function index(HOMA-β),insulin sensitivity index(ISI),insulin resistance index(HOMA-IR)],and oxidative stress indexes[total antioxidant capacity(T-AOC),malondialdehyde(MDA),superoxide dismutase(SOD)]before and after the treatment,the incidence of adverse reactions,and the incidence of adverse pregnancy outcomes were compared between the two groups.Results:After the treatment,the levels of HbA1c,2hPG and FPG in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FINS and HOMA-IR in the observation group were lower than those in the control group,the levels of HOMA-βand ISI were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of MDA in the observation group was lower than those in the control group,the level of T-AOC and SOD were higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of adverse pregnancy outcomes in the observation group was 11.11%(5/45),which was lower than 29.55%(13/44)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Bifidobacterium quadruple viable tablets combined with insulin pump in the treatment of gestational diabetes mellitus can reduce the levels of blood glucose indexes and the incidence of adverse pregnancy outcomes,and improve the levels of islet function indexes and oxidative stress indexes.Moreover,it is superior to simple insulin pump treatment.