麻黄连翘赤小豆汤加减联合常规西药治疗急性肾小球肾炎患儿的效果

Effects of modified Mahuang Lianqiao Chixiaodou decoction combined with conventional Western medicine in treatment of children with acute glomerulonephritis

目的:观察麻黄连翘赤小豆汤加减联合常规西药治疗急性肾小球肾炎患儿的效果。方法:选取2021年1月至2023年1月该院收治的69例急性肾小球肾炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组(n=34)和观察组(n=35)。两组均进行常规治疗,在此基础上,对照组采用常规西药(硝苯地平+呋塞米)治疗,观察组在对照组基础上联合麻黄连翘赤小豆汤加减治疗。比较两组临床疗效,临床相关指标(水肿消退时间、血压恢复正常时间)水平,治疗前后肾功能指标(血肌酐、血尿素氮、1 h尿红细胞排泄率、24 h尿蛋白定量)、血清学指标[胰岛素样生长因子-Ⅱ(IGF-Ⅱ)、血管内皮生长因子(VEGF)、巨噬细胞集落刺激因子(M-CSF)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为97.14%(34/35),高于对照组的76.47%(26/34),差异有统计学意义(P<0.05);观察组水肿消退时间、血压恢复正常时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组1 h尿红细胞排泄率、24 h尿蛋白定量、血肌酐、血尿素氮水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组IGF-Ⅱ、VEGF、M-CSF、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:麻黄连翘赤小豆汤加减联合常规西药治疗急性肾小球肾炎患儿可提高治疗总有效率,改善临床相关指标水平,降低肾功能指标、血清学指标水平,效果优于单纯常规西药治疗。

Objective:To observe effects of modified Mahuang Lianqiao Chixiaodou decoction combined with conventional Western medicine in treatment of children with acute glomerulonephritis.Methods:A prospective study was conducted on 69 children with acute glomerulonephritis admitted to the hospital from January 2021 to January 2023.According to the random number table method,they were divided into control group(n=34)and observation group(n=35).On this basis,the control group was treated with conventional Western medicine(Nifedipine+Furosemide),while the observation group was treated with Mahuang Lianqiao Chixiaodou decoction on the basis of that of the control group.Both groups were treated continuously for 1 month.The clinical efficacy,the clinical related indexes(edema regression time,blood pressure recovery time)levels,the renal function indexes(serum creatinine,blood urea nitrogen,1 h urinary red blood cell excretion rate,24 h urinary protein quantification)and the serological indexes[insulin-like growth factor-II(IGF-II),vascular endothelial growth factor(VEGF),macrophage colony stimulating factor(M-CSF),tumor necrosis factor-α(TNF-α)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.14%(34/35),which was higher than 76.47%(26/34)of the control group,and the difference was statistically significant(P<0.05).The edema regression time and the blood pressure recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of 1 h urinary erythrocyte excretion rate,24 h urinary protein quantification,serum creatinine and blood urea nitrogen in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IGF-II,VEGF,M-CSF and TNF-αin the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Modified Mahuang Lianqiao Chixiaodou decoction combined with conventional Western medicine in the treatment of the children with acute glomerulonephritis can improve the total effective rate of treatment,improve the levels of clinical related indexes,and reduce the levels of renal function indexes and serological indexes.Moreover,it is superior to simple conventional Western medicine treatment.