不可切除肝内胆管癌的介入治疗研究进展

Progress in interventional therapy for unresectable intrahepatic cholangiocarcinoma

肝内胆管癌(i CCA)具有隐匿性强、恶性程度高的特点,外科切除是唯一可以根治的手段,但大部分患者确诊时已错过手术时机。针对不可手术切除的i CCA,降低肿瘤负荷、减少并发症和延长生存期是主要治疗目的。介入治疗在这方面有突出的优势,可作为外科治疗的替代或补充,在国际各类指南中有着越来越重要的地位。现就目前临床上针对不可切除i CCA的消融治疗、经血管途径治疗及内照射放疗三大类介入治疗方法及其临床疗效作一综述。

Clinically,intrahepatic cholangiocarcinoma(iCCA)is characterized by high inconspicuousness and high degree of malignancy,and surgical resection is the only radical means,unfortunately,most of the patients have already missed the timing of surgery when the diagnosis of iCCA is confirmed.The main therapeutic goal for unresectable iCCA is to reduce tumor burden,reduce complications and prolong survival.Interventional therapy has outstanding advantages in this regard,it can be used as an alternative or supplement to surgical treatment,and it has already become an increasingly important part in various international guidelines.This paper reviews the currently-used three major categories of interventional therapy for unresectable iCCA(including ablation therapy,transvascular therapy and internal irradiation radiotherapy)and their clinical efficacy.(J Intervent Radiol,2024,33:796-800)