铁死亡与缺血再灌注损伤的研究进展

Research progress of ferroptosis and ischemia-reperfusion injury

铁死亡是一种程序性细胞死亡方式,涉及多分子、多信号通路,其核心过程为细胞内Fe^(2+)过载、脂质过氧化。铁死亡影响癌症、神经疾病、心血管疾病、消化系统疾病等。缺血再灌注损伤是一个极其复杂的病理过程,包括心脏、脑、肝脏、肾脏缺血再灌注损伤等,好发于休克、器官手术、器官移植,严重影响人类健康,暂无有效的根治方法。而铁死亡与缺血再灌注损伤关系紧密,探索铁死亡与缺血再灌注损伤的关系,可能寻找到缺血再灌注损伤的防治措施。同时适度调控铁死亡靶点,还可以治疗癌症、控制炎症等。本文将概述铁死亡的信号通路,以及铁死亡与心脏、脑、肝脏、肾脏缺血再灌注损伤的关系。

Ferroptosis is a kind of programmed cell death,involves multi-molecular and multi-signaling pathways,and the core processes is iron overload and lipid peroxidation.It affects cancer,neurological disease,cardiovascular disease,digestive system disease,and many other diseases.While,ischemia-reperfusion injury is an extremely complex pathological process,including ischemia-reperfusion injury of the heart,brain,liver and kidney,etc.,which often occurs in shock,organ surgery and organ transplantation,seriously affecting human health,and there is no effective radical treatment.However,ferroptosis is closely related to ischemia-reperfusion injury so that it is possible to find the prevention and treatment measures of ischemia-reperfusion injury by exploring the internal relationship between them.Therefore,the author tries to summarize the signaling pathways of ferroptosis,and explores the relationship between ferroptosis and ischemia-reperfusion injury of heart,brain,liver and kidney by moderating the ferroptosis targets properly to find the effective ways to treat cancer,improve inflammation and relieve other diseases.