支气管肺泡灌洗术联合免疫球蛋白对重症支原体肺炎患儿预后相关指标的影响分析

Analysis of the Impact of Bronchoalveolar Lavage Combined with Immunoglobulin on Prognosis Related Indicators in Children with Severe Mycoplasma Pneumonia

目的分析支气管肺泡灌洗术联合免疫球蛋白,对重症支原体肺炎患儿预后相关指标的影响。方法方便选取三明市中西医结合医院于2020年1—12月收治的126例重症支原体肺炎(Severe Mycoplasmal Pneu-monia,SMPP)患儿为研究对象,按随机数字表法分为A组、B组两组,各63例。A组接受支气管肺泡灌洗术联合激素治疗,B组接受支气管肺泡灌洗术联合免疫球蛋白治疗,持续治疗5 d,比较两组患儿治疗效果、症状改善时间、实验室指标。结果B组治疗总有效率为96.83%,高于A组的85.71%,差异有统计学意义(χ^(2)=4.881,P=0.027)。B组发热、咳嗽、干啰音、湿啰音消失时间短于A组,差异有统计学意义(P均<0.05)。治疗后,患儿白细胞、D-二聚体水平均降低,前白蛋白水平提高,且B组改善效果优于A组,差异有统计学意义(P均<0.05)。结论重症支原体肺炎患儿,提供支气管肺泡灌洗术联合免疫球蛋白治疗,可提高治疗效率,缩短症状改善时间,改善实验室指标,进而促进患儿改善预后。

Objective To analyze the impact of bronchoalveolar lavage combined with immunoglobulin on prognosis related indicators in children with severe mycoplasma pneumonia.Methods A total of 126 children with severe myco-plasmal pneumonia(SMPP)admitted to Sanming Integrated Medicine Hospital from January to December 2020 were conveniently selected as the research objects and divided into group A and group B according to the random number table method,with 63 cases in each group.Group A received bronchoalveolar lavage combined with hormone therapy,and group B received bronchoalveolar lavage combined with immunoglobulin therapy,both groups were treated for 5 days.The treatment effect,symptom improvement time and laboratory indexes were compared between the two groups.Results The total effective rate of treatment in group B was 96.83%,which was higher than 85.71%in group A,and the difference was statistically significant(χ^(2)=4.881,P=0.027).The disappearance time of fever,cough,dry rale and wet rale in group B was shorter than that in group A,and the differences were statistically significant(all P<0.05).Af-ter treatment,the levels of white blood cells and D-dimer decreased,and the level of prealbumin increased,the im-provement effect of group B was better than that of group A,and the differences were statistically significant(all P<0.05).Conclusion For children with severe mycoplasmal pneumonia,bronchoalveolar lavage combined with immuno-globulins has been shown to be effective in increasing the total response rate,shortening the time for symptom im-provement,and improving laboratory parameters,therefore,it is worth to select the best method to improve the progno-sis of the disease.