和胃降逆膏穴位贴敷联合常规止吐药物治疗肺癌化疗后恶心呕吐患者的临床效果

Clinical Effect of Hewei Jiangni Ointment Acupoint Application Combined with Conventional Antiemetic Drugs in Treatment of Lung Cancer Patients with Nausea and Vomiting After Chemotherapy

目的:探讨和胃降逆膏穴位贴敷联合常规止吐药物治疗肺癌化疗后恶心呕吐患者的临床效果。方法:选取2020年9月—2021年12月济南市第三人民医院收治的肺癌化疗后恶心呕吐患者90例作为研究对象,采用随机数字表法分为对照组与观察组,各45例。两组均实施化疗治疗,对照组采用常规止吐药物治疗,观察组在对照组基础上采用和胃降逆膏穴位贴敷治疗。比较两组中医证候积分、肿瘤标志物水平。结果:治疗前,两组恶心呕吐、乏力失眠、食欲不振、便秘积分比较,差异无统计学意义(P>0.05);治疗后,两组恶心呕吐、乏力失眠、食欲不振、便秘积分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组鳞状上皮细胞癌抗原(SCC)、癌胚抗原(CEA)、神经元特异性烯醇酶(NSE)、细胞角蛋白21-1(CYFRA21-1)水平比较,差异无统计学意义(P>0.05);治疗后,两组SCC、CEA、NSE、CYFRA21-1水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:和胃降逆膏穴位贴敷联合常规止吐药物治疗肺癌化疗后恶心呕吐患者的临床效果良好,能够改善患者症状,并能提高化疗效果,降低肿瘤标志物水平。

Objective:To explore the clinical effect of Hewei Jiangni ointment acupoint application combined with conventional antiemetic drugs in treatment of lung cancer patients with nausea and vomiting after chemotherapy.Methods:A total of 90 lung cancer patients with nausea and vomiting after chemotherapy who were admitted to Jinan Third People's Hospital from September 2020 to December 2021 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 45 cases in each group.Both groups received chemotherapy,the control group was treated with conventional antiemetic drugs,and the observation group was treated with acupoint application of Hewei Jiangni ointment on the basis of the control group.The TCM syndrome scores and tumor marker levels were compared between the two groups.Results:Before treatment,there was no significant difference in the scores of nausea and vomiting,fatigue and insomnia,loss of appetite and constipation between the two groups(P>0.05).After treatment,the scores of nausea and vomiting,fatigue and insomnia,loss of appetite and constipation in the two groups were lower than those before treatment,and the scores in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).Before treatment,there was no significant difference in the levels of squamous cell carcinoma antigen(SCC),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE)and cytokeratin 21-1(CYFRA21-1)between the two groups(P>0.05).After treatment,the levels of SCC,CEA,NSE,and CYFRA21-1 in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).Conclusion:The clinical effect of Hewei Jiangni ointment acupoint application combined with conventional antiemetic drugs is good in treatment of lung cancer patients with nausea and vomiting after chemotherapy,and can improve the symptoms of patients,enhance the effect of chemotherapy,and reduce the levels of tumor markers.