雷贝拉唑与奥美拉唑治疗消化性溃疡的效果比较

Comparison on Effect of Rabeprazole and Omeprazole in Treatment of Peptic Ulcer

目的:分析雷贝拉唑与奥美拉唑治疗消化性溃疡的效果。方法:选择2021年4月—2023年4月广州市荔湾区人民医院收治的80例消化性溃疡患者作为研究对象,随机分为雷贝拉唑组和奥美拉唑组,各40例。奥美拉唑组给予奥美拉唑肠溶胶囊治疗,雷贝拉唑组给予雷贝拉唑钠肠溶片治疗。比较两组临床疗效,反酸、腹痛消失时间,不良反应发生情况。结果:雷贝拉唑组治疗总有效率高于奥美拉唑组,差异有统计学意义(P<0.001)。雷贝拉唑组反酸、腹痛消失时间早于奥美拉唑组,差异有统计学意义(P<0.05)。雷贝拉唑组不良反应总发生率低于奥美拉唑组,差异有统计学意义(P<0.001)。治疗前,两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平比较,差异无统计学意义(P>0.05);治疗后,两组CRP、TNF-α、IL-6水平低于治疗前,且雷贝拉唑组低于奥美拉唑组,差异有统计学意义(P<0.05)。结论:相较于奥美拉唑,雷贝拉唑治疗消化性溃疡的效果显著,可快速缓解患者临床症状,降低不良反应发生率。

Objective:To analyze the effect of rabeprazole and omeprazole in the treatment of peptic ulcer.Methods:A total of 80 patients with peptic ulcer admitted to Liwan District People's Hospital of Guangzhou from April 2021 to April 2023 were selected as study subjects.The patients were randomly divided into rabeprazole group and omeprazole group with 40 cases in each group.The omeprazole group was treated with omeprazole enteric capsules,and the rabeprazole group was treated with rabeprazole sodium enteric-coated tablets.The clinical efficacy,the disappearance time of acid regurgitation and abdominal pain,and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in rabeprazole group was higher than that in omeprazole group,and the difference was statistically significant(P<0.001).The disappearance time of acid regurgitation and abdominal pain in rabeprazole group was earlier than that in omeprazole group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in rabeprazole group was lower than that in omeprazole group,and the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)between the two groups(P>0.05).After treatment,the levels of CRP,TNF-αand IL-6 in the two groups were lower than those before treatment,and the levels in rabeprazole group were lower than those in omeprazole group,with a statistically significant difference(P<0.05).Conclusion:Compared with omeprazole,rabeprazole has a significant effect in the treatment of peptic ulcer,and can quickly relieve the clinical symptoms of patients and reduce the incidence of adverse reactions.