丹参多酚酸联合丁苯酞治疗缺血性脑卒中的临床效果

Clinical effect of salvia polyphenolic acid combined with butylphthalide in the treatment of ischemic stroke

目的观察丹参多酚酸联合丁苯酞治疗缺血性脑卒中的临床效果。方法采用随机数字表法将2022年3月—2023年3月大冶市人民医院收治的缺血性脑卒中患者110例分为对症治疗组与联合注射组,各55例。对症治疗组给予常规对症治疗,联合注射组在对症治疗组基础上采用注射用丹参多酚酸联合丁苯酞氯化钠注射液治疗,2组均治疗2周。比较2组临床疗效,治疗前后血清炎性因子、神经功能评分[美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分],不良反应。结果联合注射组治疗总有效率高于对症治疗组(92.73%vs.78.18%,χ^(2)=4.681,P=0.031)。治疗2周后,2组血清肿瘤坏死因子-α、白介素-6水平低于治疗前,且联合注射组低于对症治疗组(P<0.01);2组NIHSS、mRS评分低于治疗前,且联合注射组低于对症治疗组(P<0.01)。联合注射组不良反应总发生率与对症治疗组比较,差异无统计学意义(3.64%vs.12.73%,χ^(2)=1.936,P=0.164)。结论在缺血性脑卒中的治疗中联合应用丹参多酚酸与丁苯酞,能够有效地提升治疗效果,降低炎性反应,同时可促进脑神经功能恢复,具有较高的安全性。

Objective To observe the clinical effect of salvia miltiorrhiza polyphenolic acid combined with butylphthalide in the treatment of ischemic stroke.Methods A total of 110 patients with ischemic stroke admitted to Hospital Peoples of Daye City from March 2022 to March 2023 were divided into the symptomatic treatment group and the combined injection group by random number table method,55 cases in each group.The symptomatic treatment group was treated with conventional symptomatic treatment,and the combined injection group was treated with salvia polyphenolic acid for injection combined with butylphthalide sodium chloride injection on the basis of the symptomatic treatment group,and both groups were treated for 2 weeks.The clinical efficacy,serum inflammatory factors,NIHSS score,mRS score before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the combined injection group was higher than that in the symptomatic treatment group(92.73%vs.78.18%,χ^(2)=4.681,P=0.031).After 2 weeks of treatment,the serum levels of TNF-αand IL-6 in the two groups were lower than those before treatment,and those in the combined injection group were lower than those in the symptomatic treatment group(P<0.01);The scores of NIHSS and mRS in the two groups were lower than those before treatment,and those in the combined injection group were lower than those in the symptomatic treatment group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the combined injection group and the symptomatic treatment group(3.64%vs.12.73%,χ^(2)=1.936,P=0.164).Conclusion The combination of salvia polyphenolic acid and butylphthalide in the treatment of ischemic stroke can significantly promote the treatment effect,reduce inflammation,improve neurological function of patients,and with higher safety.