窥阴器辅助不同浓度苯扎氯铵溶液阴道灌洗对妇科良性肿瘤患者阴道微生态的影响

Effects of endoscopic assisted vaginal douching with different concentrations of benzalkonium chloride solution on vaginal microecology in patients with gynecological benign tumors

目的 观察窥阴器辅助下不同浓度的苯扎氯铵溶液阴道灌洗对患者阴道微生态的影响,寻求最佳苯扎氯铵阴道灌洗浓度,为临床护理工作提供理论依据。方法 选取我院妇科住院治疗的阴道菌群密度为Ⅲ°~Ⅵ°的90例良性肿瘤患者为研究对象,随机分为试验一组,试验二组,试验三组,每组30例。入院后,给予不同阴道灌洗方案进行阴道灌洗。按照灌洗液苯扎氯铵3种不同浓度(0.02%,0.035%,0.05%)组成3种阴道灌洗方案。在灌洗前和灌洗后24 h分别取患者阴道分泌物进行菌群密度和pH值的检测,并对其进行组内和组间的比较。结果 3组患者阴道灌洗前及灌洗后24 h阴道菌群密度的组内比较差异均有统计学意义(P<0.05)。3组患者阴道灌洗前及灌洗后24 h阴道菌群密度的组间比较差异均无统计学意义(P>0.05)。3组患者阴道灌洗前及灌洗后24 h阴道pH值的组内比较差异均无统计学意义(P>0.05)。3组患者中阴道灌洗前阴道pH值在3.8~4.5的患者阴道灌洗前及灌洗后24 h阴道pH值的组间比较差异均无统计学意义(P>0.05)。结论 阴道灌洗可以使阴道菌群密度减小,对阴道pH值影响不大,阴道灌洗可以改变阴道微生态环境。不同浓度的苯扎氯铵溶液对阴道菌群密度和pH值的影响差异无统计学意义。苯扎氯铵是一种安全、刺激性小的消毒液。

Objective To examine the effects on the endoscopic assisted vaginal douching with different concentrations of benzalkonium chloride solution in determining the best concentration of benzalkonium chloride for vaginal douching,thus,providing theoretical support for clinical nursing work.Methods Ninety patients hospitalized in our hospital with benign tumor and vaginal flora density between Ⅲ and Ⅵ were selected and randomly divided into three trial groups,which were treated with different concentrations benzalkonium chloride for vaginal douching.Trial group 1,trial group 2 and trial group 3 were treated with 0.02%,0.035% and 0.05% benzalkonium chloride,respectively.The bacterial density and pH values of the vaginal secretions were examined hour 0 and hours 24 of douching,and the interclass and intergroup difference were assessed.Results The interclass differences in densities of vaginal flora between hour 0 and hours 24 of douching were statistical significance(P<0.05),whereas,the intergroup differences in density of vaginal flora between hour 0 and hours 24 of douching were not statistical significance( P>0.05).The interclass differences in vaginal pH values between hour 0 and hours 24 of douching were not statistical significance(P>0.05),and there was no statistically significant difference in vaginal pH values between hour 0 and hours 24 of douching in patients with between 3.8-4.5 vaginal pH values of three groups(P>0.05).Conclusion Vaginal douching can reduce the density of vaginal flora,it not only has a effect on vaginal pH value,but also improve a vaginal microecological environment.There were no differences in the effects of different concentrations of benzalkonium chloride solution on the density and pH of vaginal flora.Benzalkonium chloride is a safe,less irritating disinfectant.