银杏达莫注射液联合倍他司汀治疗后循环缺血眩晕的疗效分析

Effect analysis of ginkgo leaf extract and dipyridamole injection combined with betahistine in the treatment of posterior circulation ischemia vertigo

目的分析后循环缺血眩晕患者采用银杏达莫注射液联合倍他司汀治疗的临床效果。方法选取78例后循环缺血眩晕患者,按照随机数字表法分为实验组(银杏达莫注射液联合倍他司汀治疗)与对照组(倍他司汀治疗),各39例。对比两组患者临床疗效、眩晕症评分、血液粘度以及不良反应发生率。结果实验组治疗总有效率为100.00%,高于对照组的89.74%,差异显著(P<0.05)。治疗前,两组患者眩晕症状评分简化量表(VSS-SF)、眩晕障碍量表(DHI)、Berg平衡量表(BBS)评分对比无差异(P>0.05);治疗后,实验组VSS-SF、DHI、BBS评分分别为(8.22±1.04)、(10.49±1.22)、(50.49±1.22)分,均优于对照组的(12.49±1.28)、(15.67±1.45)、(35.28±1.14)分,差异显著(P<0.05)。治疗前,两组患者全血高切粘度、全血中切粘度、全血低切粘度对比无差异(P>0.05);治疗后,实验组全血高切粘度(4.57±0.49)mPa·s、全血中切粘度(5.65±0.42)mPa·s、全血低切粘度(8.62±1.31)mPa·s均低于对照组的(4.92±0.58)、(5.96±0.75)、(9.27±1.54)mPa·s,差异显著(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。结论后循环缺血眩晕采取银杏达莫注射液与倍他司汀共同治疗效果明显,可明显缓解眩晕症状,改善血液粘度,是一种安全有效的治疗方法。

Objective To analyze the clinical effect of ginkgo leaf extract and dipyridamole injection combined with betahistine in the treatment of posterior circulation ischemia vertigo.Methods A total of 78 patients with posterior circulation ischemia vertigo were selected and divided into an experimental group(ginkgo leaf extract and dipyridamole injection combined with betahistine treatment)and a control group(betahistine treatment)according to random number table method,each with 39 cases.The clinical efficacy,vertigo score,blood viscosity and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 100.00%,which was higher than 89.74%of the control group,and the difference was significant(P<0.05).Before treatment,there were no differences in vertigo symptom scale-short form(VSS-SF),vertigo disorder scale(DHI)and Berg balance scale(BBS)scores between the two groups(P>0.05).After treatment,the scores of VSS-SF,DHI and BBS in the experimental group were(8.22±1.04),(10.49±1.22)and(50.49±1.22)points,which were better than(12.49±1.28),(15.67±1.45)and(35.28±1.14)points in the control group.The difference was significant(P<0.05).After treatment,the high-shear whole blood viscosity of the experimental group was(4.57±0.49)mPa·s,the middle-shear whole blood viscosity was(5.65±0.42)mPa·s,and the low-shear whole blood viscosity was(8.62±1.31)mPa·s,which were lower than(4.92±0.58),(5.96±0.75),and(9.27±1.54)mPa·s of the control group.The difference was significant(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of ginkgo leaf extract and dipyridamole injection and betahistine for posterior circulation ischemia vertigo is effective,which can obviously relieve vertigo symptoms and improve blood viscosity,and is a safe and effective treatment method.