医药用自愈性水凝胶性能和载体研究进展

Research advances on properties and carriers of self-healing hydrogels for medical applications

自愈性水凝胶是一种具有网状结构,拥有自我修复能力的一种新型材料。这种材料一方面具有本征性的自愈性,通过动态化学键实现结构断裂后重新连接。另一方面,水凝胶具有动态的自我调节性以及生物相容性,是极具潜力的药物递送载体。该文综述了基于自愈性水凝胶在药物递送领域的研究进展,探讨了自愈性水凝胶的载药系统在药剂学的应用前景和研究方向。

Self-healing hydrogel is a novel type of material with reticular structure and self-healing capability.On the one hand,this material has intrinsic self-healing and realizes its self-healing property of structural fracture and reconnection through dynamic chemical bonding.On the other hand,hydrogels are dynamic,self-regulating and biocompatible,making them promising drug delivery vehicles.This review summarized the latest researches of self-healing hydrogels in the field of drug delivery.Also application prospects and research directions of drug-loading systems based upon self-healing hydrogels in pharmacy were discussed.