中医药调节胃肠激素水平治疗功能性便秘的研究进展

Research Progress in Treatment of Functional Constipation by Regulating Gastrointestinal Hormone Levels with Traditional Chinese Medicine

功能性便秘(Functional constipation, FC)是一种需排除肠道及全身器质性因素、药物及其他原因引起便秘的疾病,主要以腹痛、大便干结、排便困难、排便次数减少或排便不尽为特征。该病病理机制复杂,由多种原因共同造成。其中,胃肠激素水平异常是FC的重要病理特点,是当前研究消化系统疾病的热门方向。而胃肠激素是由胃肠道内分泌细胞及神经细胞释放的多种小分子活性多肽,又称胃肠肽,已超过40种为医学界所发现和鉴定出的胃肠激素。如今,国内外研究表明胃肠激素对FC具有明显调控作用,极大推动了消化系统学科的发展。中医学治疗FC经验丰富,大量研究表明中医学可以通过多靶点、多途径调控胃肠激素,有力阻断FC发生发展,从而高效治疗FC。因此,该文将从中医药调节胃肠激素水平治疗FC的角度进行综述。

Functional constipation(FC) is a disease that requires the elimination of bowel and systemic organic factors, drugs and other causes of constipation. An constipation is characterized by abdominal pain, dry stools, difficulty defecating, reduced frequency of bowel movements or a sense of incomplete bowel movements. The pathological mechanism of this disease is complex, which is caused by many reasons. Among them, the abnormal level of gastrointestinal hormone is an important pathological feature of FC,which is a popular direction in the current research of digestive system diseases. Gastrointestinal hormones are a variety of small molecule active peptides released by gastrointestinal endocrine cells and nerve cells, also known as gastrointestinal peptides, more than 40 kinds of gastrointestinal hormones have been discovered and identified by the medical community. Nowadays, domestic and foreign studies have shown that gastrointestinal hormones have obvious regulatory effects on FC,which has greatly promoted the development of digestive system. Ancestral medicine has rich experience in the treatment of FC,and a large number of studies have shown that traditional Chinese medicine can effectively block the occurrence and development of FC through multi-target and multi-channel regulation of gastrointestinal hormones, so as to effectively treat FC. Therefore, this article made the review from the perspective of TCM regulation of gastrointestinal hormone levels in the treatment of FC.