脓毒症相关急性肾损伤发病机制的研究进展

Research progress on the pathogenesis of sepsis-associated acute kidney injury

脓毒症是临床上常见的危重疾病,往往会导致多脏器受损,严重时甚至危及生命。肾脏作为脓毒症最常受累的靶器官之一使得脓毒症相关的急性肾损伤(SAKI)更容易对患者的预后产生不良影响。SAKI的发病过程十分复杂,发病机制至今尚未完全阐清,涉及免疫炎性反应、氧化应激、细胞凋亡、内皮细胞功能障碍、血流动力学异常、线粒体质量控制失调等多个方面。文章就SAKI发病机制的研究进展进行综述,以期找到SAKI有效治疗新靶点。

Sepsis is a common and critical disease in clinical practice,which often leads to multi-organ dysfunction and even life-threatening in severe cases.As one of the most commonly affected target organs of sepsis,sepsis-associated acute kidney injury(SAKI)has a more serious impact on the prognosis of patients.The pathogenesis of SAKI is very complex,involving immune inflammatory response,oxidative stress,apoptosis,endothelial cell dysfunction,hemodynamic abnormalities,mitochondrial quality control disorders and other aspects,so the pathogenesis of SAKI has not been fully elucidated.This article discusses the research progress on the pathogenesis of SAKI and briefly reviews it,in order to find new targets for the effective treatment of SAKI.