电子烟烟液中限量羰基化合物及重金属含量的准确测量

Accurate Measurement of Limited Carbonyl Compounds and Heavy Metals Content in E-Liquids

建立了高效液相色谱(HPLC)准确测定电子烟烟液中甲醛、乙醛、丙烯醛和2,3-丁二酮含量以及氢化物发生-原子荧光光谱法(HG-AFS)准确测量电子烟烟液中砷和铅含量的分析方法。电子烟烟液样品经2,4-二硝基苯肼衍生后,采用HPLC对其衍生物进行了定量分析,结果表明:HPLC方法测量羰基化合物的方法检出限为0.53~1.2μg/L、重复性为0.26%~2.2%、加标回收率为90%~103%、扩展测量不确定度为1.6%~4.5%。电子烟烟液样品经微波消解后,采用HG-AFS对砷和铅元素进行了定量分析,结果表明:HG-AFS方法测量砷和铅的方法检出限为0.007~0.025 ng/g、重复性为2.2%~4.5%、加标回收率为95%~101%、扩展测量不确定度为2.2%~3.9%。两种分析方法具有样品前处理简单、灵敏度高、测量重复性好和准确度高的优点,非常适合于准确测定电子烟烟液中限量羰基化合物及重金属的含量,进而支撑国家标准的贯彻实施和电子烟的监管。

Two analytical methods based on high-performance liquid chromatography(HPLC)and hydride generationatomic fluorescence spectroscopy(HG-AFS)were established to accurately determine four target carbonyl compounds(viz.formaldehyde,acetaldehyde,acrolein,and 2,3-butanedione)and two target heavy metals(viz.arsenic and lead)in e-liquids,respectively.After derivatization with 2,4-dinitrophenylhydrazine hydrochloride,the e-liquid samples were analyzed quantitatively by HPLC.The results showed a detection limit of 0.53-1.2μg/L,measurement repeatability of 0.26%-2.2%,spike recovery of 90%-103%,and combined uncertainty of 1.6%-4.5%.After microwave digestion,the e-liquid samples were analyzed quantitatively by HG-AFS.The results showed a detection limit of 0.007-0.025 ng/g,measurement repeatability of 2.2%-4.5%,spike recovery of 95%-101%,and combined uncertainty of 2.2%-3.9%.The two established methods have the advantages of simple sample pretreatment,high sensitivity,good repeatability,and high accuracy,making them very suitable for the accurate determination of limited carbonyl compounds and heavy metals content in e-liquids,thereby supporting the implementation of national standards and the regulation of e-cigarettes.