摘要
研究了金樱子果实中三萜成分以及抗阿尔茨海默病(AD)的活性。以神经细胞保护活性指导分离,利用硅胶、ODS及反相HPLC等柱色谱方法进行分离纯化,并利用核磁共振波谱方法进行结构鉴定。结果表明:分离的8个三萜类化合物对AChE靶蛋白有高度亲和力,并得到直接靶酶实验验证,其抑制率接近阳性药,表明金樱子三萜类成分具有抗AD活性。
The triterpenoids in Rosa laevigata Michx.fruit and their anti-Alzheimer's disease(AD)activities were studied.The neuroprotective was used to guide the isolation.The separation and purification were carried out by silica gel,ODS and reversed-phase HPLC,and the structures were identified by NMR spectroscopy.Eight triterpenoids had high affinity for AChE target proteins,and the inhibition rate was close to that of positive drugs.These results indicated that the triterpenoids had anti-AD activity.
作者
程严
刘学贵
李丹琦
高品一
CHENG Yan;LIU Xuegui;LI Danqi;GAO Pinyi(College of Pharmaceutical and Biological Engineering,Shenyang University of Chemical Technology,Shenyang Liaoning 110142,China;Institute of Functional Molecules,Shenyang University of Chemical Technology,Shenyang Liaoning 110142,China)
出处
《当代化工》
CAS
2024年第6期1282-1286,共5页
Contemporary Chemical Industry
基金
中共辽宁省委组织部-兴辽英才计划项目(项目编号:XLYC2007168)
国家自然科学基金项目(项目编号:81703377)。
关键词
金樱子
三萜类化合物
活性指导
抗阿尔茨海默病
Rosa laevigata Michx.
Triterpenoids
Activity guidance
Anti-Alzheimer's disease
