摘要
随着个性化医疗理念的深入研究,基于自体来源材料的药物递送系统受到越来越多的关注并快速发展.自体来源材料具有保留其体内天然生理学特性和优良的生物相容性等特点,这为其在材料功能化和药物递送方面开辟了广泛的研究空间,也为疾病治疗提供了坚实的基础.借助这些优势,受自体来源材料启发的药物递送系统有望在疾病治疗方面实现减毒增效.本文对基于人源蛋白、细胞材料及细胞外基质支架的药物递送系统的最新研究进行了全面回顾,重点关注了这类药物递送系统的载药策略和应用场景,深入分析了它们在疾病治疗中的优势和限制.此外,本文还探讨了受自体来源材料启发的药物递送系统在临床转化过程中面临的潜在机遇和挑战.
Pursuing personalized medicine has spurred the development of drug delivery systems inspired by autologous materials,underscoring the transition from natural origins to medicinal applications.The allure of autologous biomaterials resides in their innate functionality,exceptional biocompatibility and adaptability,facilitating surface functionalization and encapsulation of therapeutics.Leveraging these attributes,autologous material-inspired drug delivery systems have the potential to mitigate drug immune rejection while concurrently enhancing therapeutic efficacy.This review encompasses the burgeoning landscape of targeted drug delivery utilizing engineered natural origin materials,spanning human-derived proteins to cell-based materials and extracellular matrix(ECM)scaffolds.By emphasizing the intrinsic attributes of these materials and strategies for drug loading,this review provides insights into the potential and challenges inherent in this field.
作者
冯慧珩
程伊安
柳扶摇
顾臻
李洪军
Huiheng Feng;Irina Cheng;Fuyao Liu;Zhen Gu;Hongjun Li(State Key Laboratory of Advanced Drug Delivery and Release Systems,and Liangzhu Laboratory,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Jinhua Institute of Zhejiang University,Jinhua 321299,China;Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Department of General Surgery,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China;MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China;Department of Hepatobiliary and Pancreatic Surgery,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China)
基金
supported by the National Key R&D Program of China(2021YFA0909900)to Gu Z,the National Natural Science Foundation of China(52233013)to Gu Z
the National Natural Science Foundation of China(52173142)to Li H
the grants from the Startup Package of Zhejiang University to Gu Z and Li H.
