摘要
近年来,纳米技术的进步为刺激响应型微纳机器人的发展奠定了基础,它们在癌症治疗中扮演着“智能战士”的角色.本文首先总结了各种刺激响应的机制,包括磁场、光、超声、pH和过氧化氢等介导的刺激响应,这些机制被用于触发肿瘤微环境中微纳机器人的运动和药物释放.随后,本文系统地归纳了用于化疗药物递送的微纳机器人的发展历程与最新进展.值得注意的是,虽然这些“智能战士”在精准化疗药物递送方面具有潜在的应用价值,但要充分发挥它们的作用,还需要持续的探索,以应对实现其在复杂体内微环境中的运动所面临的挑战.
Because of the high heterogeneity and adaptability[1],the clinical treatment of cancer faces significant challenges,emerging as an urgent public health concern.Chemotherapy stands as one of the widely used methods for treating cancer,employing cytotoxic drugs to halt the proliferation of cancer cells by inducing cell death or inhibiting cell division.However,chemotherapeutic drugs present the problems of poor solubility,limited tissue-specificity,short blood circulation,multidrug resistance,and toxic side effects,which seriously restrict their therapeutic efficacy and further clinical applications[2,3].
作者
马然
侯仰龙
王術人
Ran Ma;Yanglong Hou;Shuren Wang(Beijing Key Laboratory for Magnetoelectric Materials and Devices(BKL-MMD),School of Materials Science and Engineering,Peking University,Beijing 100871,China;School of Materials,Sun Yat-sen University,Shenzhen 518107,China)
基金
financially supported by the National Natural Science Foundation of China(52201198,52027801,and 92263203)
the Beijing Natural Science Foundation-Haidian Primitive Innovation Joint Fund(L232015)
the National Key R&D Program of China(2022YFA1203902)
the China-Germany Collaboration Project(M-0199).
