基于双频HIFU换能器的振动声成像及其靶组织损伤区域检测研究

Vibration Acoustic Imaging and Damage Area Detection of Target Tissue Based on Dual-Frequency HIFU Transducer

HIFU作为一种无创、无电离辐射的物理治疗技术已经被用于各种良、恶性实体肿瘤的治疗。但HIFU临床治疗依然面临一个关键问题:基于传统的超声影像依然不能对HIFU治疗后靶组织损伤的区域进行清晰成像。针对该问题,将振动声成像方法引入到HIFU治疗系统中,将常规单频激励的HIFU换能器改造成双频HIFU换能器,并利用该换能器进行双频HIFU治疗及靶组织损伤区域的振动声成像。基于该系统首先研究了不同频差对换能器聚焦性能和焦域尺寸的影响以及不同结构的仿体组织、不同成像深度对振动声成像质量的影响。然后,以仿体和离体组织作为HIFU辐照对象,开展了HIFU辐照靶组织损伤区域可视化的振动声成像实验。实验结果表明:不同结构和特性仿体组织的振动声成像对比度较好、空间分辨率较高。此外,当HIFU辐照仿体和离体组织后,基于该成像方式能够实现靶组织损伤区域的可视化,这有望为HIFU治疗后靶组织的损伤区域检测提供一种有应用前景的解决方案和途径,提高HIFU治疗的有效性和安全性。

As a non-invasive,influential physical therapy technology,HIFU has been used for the treatment of various benign and malignant physical tumors.However,HIFU clinical treatment still faces a key problem,i.e.,based on traditional ultrasonic images,the damage area of the target tissue after HIFU treatment cannot be imaged.In response to this problem,the vibration sound imaging method is introduced into the HIFU treatment system,conventional single-frequency incentives HIFU transcoders are transformed into a dualfrequency HIFU converter,and the converter is used for dual-frequency HIFU treatment and vibration imaging of the damaged area of the target tissue.Based on this system,the effects of frequency differences on the focusing performance and size of focus domain,as well as the effects of imitation tissue and different imaging depths on the quality of vibration imaging are studied.Then,with the imitation tissue and separated tissue as the radiation targets,visual vibrating imaging experiments of the damage areas of HIFU radiation target tissues are carried out.The experimental results show that the vibration imaging of different structures and characteristics of imitation tissue are better and the spatial resolution is high.In addition,the proposed imaging method provides on approch with application prospect for the damage area detection of HIFU treatment target tissue,improving the effectiveness and safety of HIFU treatment.