咪达唑仑口服液对患儿术后恢复时间的影响研究

Study on the Effect of Midazolam Oral Liquid on Postoperative Recovery Time in Children

分析咪达唑仑口服液对患儿术后恢复时间的影响。选取贵州省安顺市人民医院收治的60例手术患儿为研究对象,随机将其分为对照组和观察组两组,每组各30例。对照组采取丙泊酚+舒芬太尼+维库溴铵诱导全身麻醉后手术,观察组在全身麻醉诱导前20 min,指导患儿口服咪达唑仑口服液,待其进入镇静状态后再行与对照组完全相同的全麻诱导后手术,对比两组患儿麻醉效果及术后苏醒时间。结果显示,麻醉前,两组患儿各项血流动力学指标比较,无统计学差异(P>0.05);气腹后30 min、拔管后3 min,观察组患儿的各项血流动力学指标均优于对照组(P<0.05);观察组患儿麻醉起效时间短于对照组,自主呼吸恢复时间长于对照组,苏醒时间长于对照组,拔管时间长于对照组,组间差异具有统计学意义(P<0.05);术后1天,观察组患儿的各项氧化应激反应指标均优于对照组(P<0.05)。研究发现,对于接受手术治疗的患儿实施咪达唑仑口服液镇静后行全身麻醉诱导,可改善患儿麻醉指标,缓解患儿不良情绪,稳定患儿生命体征,患儿苏醒后无哭闹、烦躁等情况出现,麻醉安全性较高。

Analyze the impact of midazolam oral solution on postoperative recovery time in pediatric patients.Sixty surgical children admitted to People’s Hospital of Anshun City were selected as the research subjects and randomly divided into a control group and an observation group,with 30 cases in each group.The control group underwent surgery after induction of general anesthesia with propofol,sufentanil,and vecuronium bromide.The observation group was instructed to orally administer midazolam oral solution 20 minutes before induction of general anesthesia.After entering a sedative state,the same general anesthesia induction surgery as the control group was performed.The anesthesia effect and postoperative recovery time of the two groups of children were compared.The results showed that before anesthesia,there was no statistically significant difference in various hemodynamic indicators between the two groups of children(P>0.05);30 minutes after pneumoperitoneum and 3 minutes after extubation,the hemodynamic indicators of the observation group were superior to those of the control group(P<0.05);The anesthesia onset time of the observation group was shorter than that of the control group,the recovery time of spontaneous breathing was longer than that of the control group,the awakening time was longer than that of the control group,and the extubation time was longer than that of the control group.The differences between the groups were statistically significant(P<0.05);On thefirst day after surgery,all oxidative stress response indicators in the observation group were superior to those in the control group(P<0.05).Research has found that for children undergoing surgical treatment,sedation with midazolam oral solution followed by general anesthesia induction can improve anesthesia indicators,alleviate negative emotions,stabilize vital signs,and prevent crying,irritability,and other symptoms after awakening.Anesthesia safety is relatively high.