重组人生长激素治疗儿童特发性矮小症的临床效果研究

Clinical Efficacy Analysis of Recombinant Human Growth Hormone in the Treatment of Idiopathic Short Stature in Children

探究重组人生长激素治疗儿童特发性矮小症的临床效果。选取铜仁西南妇女儿童医院2019年7月-2020年6月收治的80例特发性矮小症患儿为研究对象,随机将患儿分为对照组和观察组两组,每组各40例。对照组患儿实施常规胰岛激素治疗,观察组患儿实施重组人生长激素治疗,整体评估治疗后患儿各项情况。结果显示,治疗后,观察组患儿的碱性磷酸酶和生长激素水平均优于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患儿的体质量、身高、身高标准差积分以及生长速度均优于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患儿的骨龄和头围指标均优于对照组,差异具有统计学意义(P<0.05);两组患儿的不良反应发生情况比较,无统计学差异(P>0.05)。研究发现,重组人生长激素治疗儿童特发性矮小症效果明显,可优化患儿的相关指标,治疗安全性较高。

Exploring the clinical efficacy of recombinant human growth hormone in the treatment of idiopathic short stature in children.Eighty children with idiopathic short stature admitted to Southwest Women and Children’s Hospital from July 2019 to June 2020 were selected as the research subjects.The children were randomly divided into a control group and an observation group,with 40 cases in each group.The control group received conventional insulin therapy,while the observation group received recombinant human growth hormone therapy.Overall evaluate the patient’s condition after treatment.The results showed that after treatment,the levels of alkaline phosphatase and growth hormone in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05);After treatment,the body mass,height,height standard deviation score,and growth rate of the observation group were better than those of the control group,and the differences were statistically significant(P<0.05);After treatment,the bone age and head circumference indicators of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05);There was no statistically significant difference(P>0.05)in the occurrence of adverse reactions between the two groups of children.Research has found that recombinant human growth hormone therapy has a significant effect on children with idiopathic short stature,can optimize relevant indicators in children,and has high treatment safety.