芳姜黄酮衍生物的设计合成及其抑菌活性研究

DESIGN,SYNTHESIS AND ANTIFUNGAL ACTIVITY OF AR-TURMERONE DERIVATIVES

为了寻找具有较高活性的芳姜黄酮类衍生物,根据芳姜黄酮的结构特点,对其进行了针对性的修饰,并利用1H NMR和13C NMR等技术将其结构进行表征;同时采用梯度稀释方法制备不同浓度的化合物溶液,将制备好的溶液进行平板涂布,确定化合物的最低抑菌浓度。实验结果表明:设计合成的7个(A~G)新型衍生物对尖孢镰刀菌均表现出了不同程度的抑制效果。其中,化合物E、F的抑菌效果最为显著;化合物B、C、D、G的抑菌活性较强;而化合物A的抑菌效果相对较弱。本研究结果可以为未来在芳姜黄酮类药物研发领域提供参考作用。

The aim of this paper is to try to find high biological ar-turmerone derivatives.According to the structural characteristics of ar-turmerone,it was modified and its structure was characterized by 1H NMR and 13C NMR;At the same time,the compound solutions of different concentrations were prepared by gradient dilution method,and the prepared solutions were coated on a plate to determine the minimum antifungal concentration of the compound.The results showed that the seven new derivatives(A-G)designed and synthesized showed different degrees of inhibitory effects on Fusarium oxysporum.Among them,the antifungal effects of compounds E and F were the most significant;compounds B,C,D and G had strong antifungal activity;The antifungal effect of compound A was relatively weak.This study can provide certain reference basis for future research and development in the field of ar-turmerone drugs.