张震“疏调气机”思想论治系统性红斑狼疮经验

Zhang Zhen's experience in the treatment of systemic lupus erythematosus with the thought of regulating qi movement

系统性红斑狼疮(SLE)为全身多系统受累的自身免疫性疾病,可归属中医学“阴阳毒”范畴。国医大师张震教授认为,系统性红斑狼疮为本虚标实之症,病因病机以肝脾肾虚为本,毒瘀血脉为标,且SLE患者普遍存在情志失调,应身心同治,提出“疏调气机,一体两翼”学术思想,自拟疏调生血汤治疗系统性红斑狼疮,治法着眼于疏肝,健脾补肾并重,辅以解毒化瘀生血。现代药理研究显示,该方具有抗炎、调节免疫、促进血小板再生等作用,可从各个环节调控SLE发展的相关生物过程,从而改善SLE症状、抑制SLE病情进展,可在临床推广应用。

Systemic lupus erythematosus(SLE)is an autoimmune disease that involves multiple systems throughout the body,and can be classified under the category of"yin-yang poisoning"in traditional Chinese medicine.Professor Zhang Zhen,a master of traditional Chinese medicine,believed that SLE was a syndrome of defi ciency in origin and excess in superfi ciality,and the etiology and pathogenesis of SLE were based on liver,spleen and kidney deficiency,with toxin stasis blood and vessels as the standard.Professor Zhang believed that SLE patients generally had emotional disorders and should be treated both physically and mentally simultaneously.Professor Zhang proposed academic idea of"regulating qi movement,and using liver as the main body and spleen and kidney as the wings",and used self-formulated Shutiao Shengxue Tang to treat SLE,and his treatment method focused on dispersing stagnated liver qi,and invigorating the spleen and kidney,supplemented by detoxication,removing blood stasis,and production of blood.The results of modern pharmacological research suggest that this prescription has antiinflammatory,immune regulation and promoting platelet regeneration eff ects,and can regulate the relevant biological processes of the development of SLE from various aspects,thereby improving SLE symptoms and inhibiting the progression of SLE.This therapy can be promoted and applied in clinical practice.