沙参麦冬汤加减治疗急腹症术后胃阴虚证

Clinical effi cacy of modifi ed Radix Ophiopogon soup in the treatment of syndrome of defi ciency of stomach yin after acute abdominal surgery

目的探讨沙参麦冬汤加减治疗急腹症术后胃阴虚证的临床疗效及对急性应激反应的影响。方法选取104例急腹症术后胃阴虚证患者,按照随机数表法分为研究组与对照组,各52例。对照组采用常规西药治疗,研究组另给予沙参麦冬汤加减治疗。比较2组患者症状缓解时间,中医症状评分,临床疗效,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)水平及不良反应发生情况。结果研究组患者肠鸣音恢复、术后肛门排气、体温恢复时间均短于对照组(P<0.05);治疗后,2组腹胀、腹痛、大便秘结、胃纳减退、恶心呕吐、舌红少津评分均降低(P<0.05),且研究组均低于对照组(P<0.05);研究组总有效率(94.23%,49/52)高于对照组(80.77%,42/52)(P<0.05);治疗后,2组血清SOD、GSH-Px水平均升高(P<0.05),且研究组高于对照组(P<0.05);治疗后,2组血清IL-1β、TNF-α水平均降低(P<0.05),且研究组低于对照组(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论沙参麦冬汤加减治疗急腹症术后胃阴虚证患者,能够改善临床症状,减轻急性应激反应,疗效确切,安全可靠。

Objective To explore the clinical efficacy of modifi ed Radix Ophiopogon soup on syndrome of defi ciency of stomach yin after acute abdominal surgery and its infl uence on acute stress response.Methods 104 patients with syndrome of defi ciency of stomach yin after acute abdominal surgery were selected and divided into the study group and the control group according to random number table method,with 52 cases in each group.The control group received conventional Western medicine treatment,and the study group received treatment with modified Radix Ophiopogon soup.Symptom relief time,traditional Chinese medicine(TCM)symptom score,clinical efficacy,levels of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),interleukin 1β(IL-1β)and tumor necrosis factorα(TNF-α),and occurrence of adverse reactions in both groups were compared.Results The recovery time of bowel sounds and postoperative body temperature,and postoperative anal exhaust time in the study group were shorter than those in the control group(P<0.05).After treatment,the scores of abdominal distension,abdominal pain,constipation,anorexia,nausea and vomiting,red and dry tongue in both groups decreased(P<0.05),and the study group was lower than the control group(P<0.05).The total effective rate of the study group(94.23%,49/52)was higher than that of the control group(80.77%,42/52)(P<0.05).After treatment,the levels of serum SOD and GSH-Px in two groups increased(P<0.05),and the study group was higher than the control group(P<0.05).After treatment,the levels of IL-1βand TNF-αin two groups decreased(P<0.05),and the study group was lower than the control group(P<0.05).There was no statistically signifi cant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion The modified Radix Ophiopogon soup has the defi nite therapeutic eff ect on patients with syndrome of defi ciency of stomach yin after acute abdominal surgery.This therapy can improve clinical symptoms,alleviate acute stress response of the patients,and is safe and reliable.