队列研究在中医药防治糖尿病疗效评价领域的应用与思考

Application and Considerations of Cohort Study in Effectiveness Evaluation of Traditional Chinese Medicine in the Prevention and Treatment of Diabetes

通过系统分析目前中医药防治糖尿病的疗效评价研究结果及其推广困境,认为队列研究作为观察性研究方法,更适用于评价中医药防治糖尿病这类复杂且个体化的干预措施。结合前瞻性队列研究的设计特点与相关实践,针对性地提出将以“态靶辨治”为核心、“分类-分期-分证”为框架的糖尿病现代中医诊疗体系作为顶层设计,开展前瞻性队列研究,围绕重视个体化防治、长周期多维度评价疗效,深入探讨前瞻性队列研究应用于中医药防治糖尿病疗效评价的优势与价值,以期为糖尿病中医药防治临床研究提供思路。

Through the systematic analysis of the current research results on the effectiveness of traditional Chinese medicine(TCM)in the prevention and treatment of diabetes and its promotion dilemma,it is believed that cohort study,as an observational research method,is particularly suitable for evaluating complex and individualized interventions such as traditional Chinese medicine in the prevention and treatment of diabetes.Considering the design features and relevant practices of prospective cohort studies,it is specifically proposed to carry out prospective cohort studies using a modern TCM diagnostic and treatment system for diabetes,centered on"state-targeted differentiation and treatment",and framed by"classification-staging-syndrome differentiation".Focused on personalized prevention and treatment,long-term multidimensional assessment of therapeutic effectiveness and syndrome changes,this paper gives in-depth exploration of the advantages and value of applying prospective cohort studies in the effectiveness evaluation of TCM in prevention and treatment of diabetes,aiming to provide insights for clinical researches on TCM for diabetes.