清肺消炎丸联合左氧氟沙星注射液治疗某军校官兵肺炎支原体肺炎的效果研究

Therapeutic Effect of Qingfeixiaoyan Pill Combined with Levofloxacin Injection in the Treatment of Mycoplasma Pneumoniae Pneumonia in Officers and Soldiers of A Certain Military Academy

目的分析作者单位学员官兵使用清肺消炎丸联合左氧氟沙星注射液治疗肺炎支原体肺炎(mycoplasmal pneumoniae pneumonia,MPP)的效果。方法选取2023-10~11月作者单位门诊部收治的55例MPP患者为研究对象。采用随机双盲法将MPP患者分为观察组(n=28)和对照组(n=27)。对照组患者静脉滴注左氧氟沙星注射液0.5g/次,1次/天及对症支持治疗,观察组患者在对照组的治疗方案上联合口服清肺消炎丸60丸/次,3次/天。治疗10天后比较两组患者的临床疗效总有效率、炎症因子水平、临床症状(咳嗽、乏力与发热)持续时间和不良反应(adversereaction,AR)发生率。结果观察组临床疗效总有效率高于对照组(P<0.05)。治疗后,两组患者炎症因子水平均低于治疗前,且观察组炎症因子水平低于对照组,临床症状持续时间显著低于对照组(P均<0.05),但两组AR发生率比较差异无统计学意义(P>0.05)。结论清肺消炎丸联合左氧氟沙星注射液治疗MPP不仅能提高患者治疗总有效率,减轻炎症反应,还能缩短临床症状持续时间。

Objective To analyze the therapeutic effects of Qingfeixiaoyan Pill combined with levofloxacin injection during the outbreak of mycoplasmal pneumoniae pneumonia(MPP)among students in author's hospital.Methods A to-tal of 55 patients with MPP admitted to the outpatient department of the author's hospital from October to November 2023 were selected as the research objects.The MPP patients were divided into observation group(n=28)and control group(n=27)by randomized double-blind trial.The patients in the control group were treated with levofloxacin injec-tion 0.5 g/time,1 time/day and symptomatic and supportive treatment,and the patients in the observation group were treated with Qingfeixiaoyan Pill 60 pills/time,3 times/day on the treatment plan of the control group.The total effective rate of clinical efficacy,inflammatory factor levels,duration of clinical symptoms(cough,fatigue and fever)and incidence of adverse reaction(AR)were compared between the two groups.Results The total effective rate in the observation group was higher than that of the control group(P<0.05).After treatment,the levels of inflammatory factors in the two groups were lower than those before treatments,and the levels of inflammatory factors of patients in the observation group were lower than those in the control group,and the duration of clinical symptoms was significantly lower than that in the control group(all P<0.05),however,there was no significant difference in the incidence of AR between the two groups(P>0.05).Conclusion The combination of Qingfeixiaoyan Pill and levofloxacin injection in the treatment of MPP can not only improve the treatment effecuiveness of the patients,but also reduce inflammatory response,shorten the duration of clinical symptoms.