摘要
纳米技术作为一项前沿技术在医药领域发挥着重要作用,为治疗许多疾病提供了新的思路和方法。其中金属有机骨架材料(MOFs)由于其特殊的性质及在疾病治疗相关领域的优势,人们越来越关注到其的相关应用。沸石咪唑酯骨架-8(ZIF-8)是金属有机骨架材料中的一种,其具有比表面积大,稳定性高,孔径可控,低毒性等优点,作为纳米载体近些年来被广泛研究,本文概述了ZIF-8的一些特点,介绍了其载药方式以及在肝脏相关疾病的一些研究和应用实例,并对其未来的应用进行展望。
As a cutting-edge technology,nanotechnology plays an important role in the field of medicine,pro-viding new ideas and methods for the treatment of many diseases.Metal-organic framework materials(MOFs)have at-tracted more and more attention due to their special properties and advantages in the field of disease treatment.Zeolite imidazolate framework-8(ZIF-8)is a kind of metal-organic skeleton material,which has the advantages of large specif-ic surface area,high stability,controllable pore size,low toxicity,etc.It has been widely studied as a nanocarrier in recent years.This paper summarizes some characteristics of ZIF-8,introduces its drug loading mode,and some re-search and application examples in liver diseases.
作者
邵瑞龙
柳安雄
叶啟发
钟自彪
ShaoRuilong;LiuAnxiong;YeQifa;ZhongZibiao(Gstitute of Hepatobiliary Diseases,Zhongnan Hospital,Wuhan University,Institute of Hepatobiliary Diseases of Wuhan,University,Transplant Center of Wuhan University,Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,China;Department of Transplantation,the 3rd Xiangya Hospital,Central South University,Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Changsha 410013,China)
出处
《中华实验外科杂志》
CAS
2024年第7期1639-1643,共5页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金(82370758)
湖北省重点研发项目(2021BCA122)。
