中性粒细胞在心肌缺血再灌注损伤中作用的研究进展

Advancements in research regarding the involvement of neutrophils in myocardial ischemia-reperfusion injury

中性粒细胞是心肌缺血再灌注后响应最迅速、数量最丰富的细胞,在启动炎症和组织修复中具有重要作用。本文重点概述了中性粒细胞的生理特点、生物学功能以及不同亚群之间的异质性,总结以中性粒细胞为中心介导的炎症级联反应在心肌缺血再灌注损伤进展中的重要作用,阐述多种靶向中性粒细胞调控的策略及其应用情况和转化前景。

Neutrophils are the most responsive and abundant cells following myocardial ischemia-reperfusion, playing a crucial role in both inflammation and tissue repair. This paper provides a comprehensive summary of the physiological characteristics and biological functions of neutrophils, as well as the heterogeneity among different subpopulations. It also highlights the significant role of neutrophil-mediated inflammatory cascade in myocardial ischemia-reperfusion injury. Additionally, the paper reviews various regulatory strategies targeting neutrophils, discussing their application and potential for translation to clinical practice thus far.