丁苯酞联合雷沙吉兰治疗老年帕金森病的效果研究

Therapeutic effect of butylphthalide combined with rasagiline on Parkinson disease in elderly patients

目的分析丁苯酞联合雷沙吉兰治疗老年帕金森病(PD)的效果。方法队列研究。抽取2020年10月至2023年5月郑州大学附属郑州中心医院收治的老年PD患者60例为研究对象,按照随机数字表法分为对照组与研究组,每组30例。对照组采用雷沙吉兰治疗,研究组在对照组基础上采用丁苯酞治疗。比较两组疗效及不良反应发生率。比较两组治疗前后血清C反应蛋白(CRP)水平、同型半胱氨酸(Hcy)水平、统一帕金森评分量表(UPDRS)评分和认知功能[蒙特利尔认知评估量表(MoCA)]评分。结果研究组总有效率(93.33%,28/30)高于对照组(73.33%,22/30),P<0.05。治疗前,两组CRP、Hcy水平比较差异未见统计学意义(P>0.05);治疗后,研究组CRP、Hcy水平低于对照组(P<0.05)。治疗前,两组UPDRS、MoCA评分比较差异未见统计学意义(P>0.05);治疗后,研究组UPDRS评分低于对照组,MoCA评分高于对照组(P<0.05)。研究组不良反应发生率(13.33%,4/30)与对照组(6.67%,2/30)比较差异未见统计学意义(P>0.05)。结论丁苯酞联合雷沙吉兰治疗老年PD疗效显著,能改善患者临床症状及神经功能,提升其认知功能,且不良反应较少。

Objective To analyze the effect of butylphthalide combined with rasagiline in the treatment of elderly patients with Parkinson disease.Methods This study was a cohort trail.A total of 60 elderly patients with PD treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from October 2020 to May 2023 were selected,and they were divided into control group and study group by random number table method,with 30 cases in each group.The control group was treated with rasagiline,and the study group was treated with butylphthalide based on the treatment of the control group.The curative effect and incidence of adverse reactions were compared between the two groups.The levels of serum C-reactive protein(CRP)and homocysteine(Hcy),unified Parkinson disease rating scale(UPDRS),cognitive function assessed by Montreal cognitive assessment(MoCA)score were compared between the two groups before and after treatment.Results The total effective rate of the study group(93.33%,28/30)was higher than that of the control group(73.33%,22/30),P<0.05.There was no significant difference in preoperative levels of CRP and Hcy between the two groups(P>0.05).After treatment,the levels of CRP and Hcy in the study group were lower than those in the control group(P<0.05).There was no significant difference in UPDRS and MoCA scores between the two groups before treatment(P>0.05).After treatment,the study group had lower UPDRS score and higher MoCA score,compared with the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group(13.33%,4/30)and the control group(6.67%,2/30),P>0.05.Conclusions Butylphthalide combined with rasagiline had an ideal effect in the treatment of elderly patients with PD,which can improve clinical symptoms,neurological function and cognitive function,with fewer adverse reactions.