黑蒜多酚联合多奈哌齐治疗早期阿尔茨海默病的疗效观察

目的 探讨黑蒜多酚联合西药治疗早期阿尔茨海默病(AD)的疗效。方法 选取2019年3月至2020年3月本院收治的120例早期AD患者,随机分为观察组和对照组,各60例,观察组予黑蒜多酚联合多奈哌齐治疗,对照组予多奈哌齐单药治疗,持续治疗12周。采用简易智力状态检查量表(MMSE)、长谷川痴呆量表(HDS)、简明精神病评定量表(BPRS)等对两组患者认知功能、日常生活能力和精神状况进行评定,同时检测血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)的活性和丙二醛(MDA)水平,并记录治疗期间的不良反应。结果 观察组治疗有效率80.00%,对照组有效率61.67%,两组差异有统计学意义(P<0.05);观察组治疗后的MMSE评分和HDS评分高于对照组,而ADL评分和BPRS评分明显低于对照组(P<0.05),且血清SOD和GSH-PX活性明显升高(P<0.05),MDA水平明显下降(P<0.05)。结论 黑蒜多酚联合多奈哌齐治疗早期AD患者有明显疗效,可减缓认知功能衰退,改善精神行为症状。

Objective To investigate the therapeutic effect of black garlic polyphenols in combination with western medicine on patients diagnosed with early-stage Alzheimer's disease(AD).Methods 120 patients with early AD admitted to our hospital from March 2019 to March 2020 were selected and randomly divided into an observation group and a control group,60 cases each,who received black garlic polyphenols combined with donepezil and donepezil monotherapy for 12 weeks,respectively.Before and after the treatment,the cognitive function,daily living ability and mental status of the patients in each group were evaluated by using the Brief Mental State Examination Scale(MMSE),Hasegawa Dementia Scale(HDS),Brief Psychiatric Rating Scale(BPRS),etc.Meanwhile,the activities of serum superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),and malondialdehyde(MDA)were measured.levels,and adverse effects during treatment were recorded.Results The treatment efficiency of the observation group was 80.00%,and that of the control group was 61.67%,and the difference in the total efficiency between the two groups was statistically significant(P<0.05).The MMSE scores and HDS scores of the observation group were significantly higher than those of the control group,whereas the ADL scores and BPRS scores were significantly lower than those of the control group after the treatment(P<0.05),and the activities of serum SOD and GSH-PX were significantly elevated(P<0.05),and MDA levels were significantly decreased(P<0.05).Conclusion Black garlic polyphenols combined with donepezil have significant efficacy in treating patients with early AD,slowing cognitive decline and improving psychobehavioral symptoms.