带状疱疹脑膜炎患者认知功能的变化

目的 探讨带状疱疹脑膜炎患者的认知功能变化。方法 选取2020年1月至2022年12月经脑脊液水痘-带状疱疹病毒DNA确诊的带状疱疹脑膜炎患者23例及健康体验者28例(对照组),采用蒙特利尔认知评价量表(MoCA)评估其认知功能,并分析患者的认知功能改变。结果 23例带状疱疹脑膜炎患者有6例患者存在认知功能下降。与对照组比较,带状疱疹脑膜炎患者MoCA评分(25.88±2.31 VS.27.61±1.81)明显降低(P<0.05);其中视空间执行功能(3.29±1.12 VS. 4.11±0.92)、延迟回忆(4.21±0.66 VS. 4.57±0.50)明显降低,差异有统计学意义(P<0.05)。结论 带状疱疹脑膜炎患者早期可出现以视空间执行功能、延迟回忆为主的认知障碍,临床医师要重视带状疱疹脑膜炎患者的认知功能筛查。

Objective To explore the change of cognitive function in patients with varicella zoster virus(VZV)meningitis.Methods 23 patients with VZV meningitis diagnosed with cerebrospinal fluid VZV DNA positive who were hospitalized in our hospital from January 2020 to December 2022 were selected as the research subjects and 28 people who came to physical examination as the control group.Their cognitive functions were evaluated using the Montreal Cognitive Assessment Scale(MoCA).Results 6 of the 23 patients with VZV meningitis had cognitive decline.Compared with that of the control group,the MoCA scores of VZV meningitis patients was much impaired(25.88±2.31 VS.27.61±1.81,P<0.05),visual-spatial executive function(3.29±1.12 VS.4.11±0.92)and delayed recall(4.21±0.66 VS.4.57±0.50)were significantly decreased,with statistically significant differences(P<0.05).Conclusion Patients with VZV meningitis had cognitive dysfunction in the early stages.The main cognitive abnormalities were visualspatial executive function and delayed recall.Clinicians should pay attention to the cognitive function screening of patients with VZV meningitis.