肺炎支原体抗体联合超敏C反应蛋白检测诊断小儿早期肺炎支原体肺炎的价值

Value of Mycoplasma pneumoniae antibody combined with hypersensitive C⁃reactive protein detection in the diagnosis of early mycoplasma pneumoniae pneumonia in children

目的研究肺炎支原体抗体(MP-Ab)联合超敏C反应蛋白(hs-CRP)检测诊断小儿早期肺炎支原体肺炎(MPP)的价值。方法选取2020年1月至2022年12月南阳市中心医院收治的疑似MPP感染患儿82例为研究对象,均进行MP-Ab和hs-CRP检测,以病原学检查结果为“金标准”,统计MP-Ab和hs-CRP单独检测与联合检测对MPP的诊断结果和诊断效能,分析预测值。结果本研究82例疑似MPP患儿中,经病原学检查确诊阳性37例,阴性45例;MP-Ab诊断出真阳性28例,真阴性35例;hs-CRP诊断出真阳性27例,真阴性36例;二者联合诊断出真阳性36例,真阴性43例;二者联合诊断灵敏度[97.30%(36/37)]、特异度[95.56%(43/45)]、准确度[96.34%(79/82)]较MP-Ab诊断[75.68%(28/37)、77.78%(35/45)、76.83%(63/82)]和hs-CRP诊断[72.97%(27/37)、80.00%(36/45)、76.83%(63/82)]高,漏诊率[2.70%(1/37)]、误诊率[4.44%(2/45)]较MP-Ab诊断[24.32%(9/37)、22.22%(10/45)]和hs-CRP诊断[27.03%(10/37)、20.00%(9/45)]低(P<0.05);二者联合诊断阳性预测值[94.74%(36/38)]、阴性预测值[97.73%(43/44)]较MP-Ab诊断[73.68%(28/38)、79.55%(35/44)]和hs-CRP诊断[75.00%(27/36)、78.26%(36/46)]高(P<0.05)。结论MP-Ab联合hs-CRP检测应用于早期MPP患儿中,能明显提高诊断灵敏度、准确度、特异度,减少漏诊和误诊情况的发生,且预测值良好。

Objective To study the value of mycoplasma pneumoniae antibody(MP⁃Ab)combined with hypersensitive C⁃reactive protein(hs⁃CRP)detection in the diagnosis of early mycoplasma pneumoniae pneumonia(MPP)in children.Methods A total of 82 children with suspected MPP in Nanyang Central Hospital from January 2020 to December 2022 were selected.Both MP⁃Ab and hs⁃CRP levels were detected.Taking the results of pathogen examination as the"gold standard",the diagnostic results and diagnostic efficacy of MP⁃Ab,hs⁃CRP single detection and combined detection were analyzed,and the predictive value was analyzed.Results Among the 82 children with suspected MPP,37 cases were positive and 45 cases were negative diagnosed by etiological examination;28 cases were true positive and 35 cases were true negative diagnosed by MP⁃Ab;27 cases were true positive and 36 cases were true negative diagnosed by hs⁃CRP;36 cases were true positive and 43 cases were true negative diagnosed by the combination of the two methods.The sensitivity,specificity and accuracy of combined diagnosis[97.30%(36/37),95.56%(43/45),96.34%(79/82)]were higher than those of MP⁃Ab diagnosis[75.68%(28/37),77.78%(35/45),76.83%(63/82)]and hs⁃CRP diagnosis[72.97%(27/37),80.00%(36/45),76.83%(63/82)],and the rate of missed diagnosis and misdiagnosis[2.70%(1/37),4.44%(2/45)]were lower than those of MP⁃Ab diagnosis[24.32%(9/37),22.22%(10/45)]and hs⁃CRP diagnosis[27.03%(10/37),20.00%(9/45)](P<0.05).The positive predictive value and negative predictive value of the combined diagnosis[94.74%(36/38),97.73%(43/44)]were higher than those of MP⁃Ab[73.68%(28/38),79.55%(35/44)]and hs⁃CRP[75.00%(27/36),78.26%(36/46)](P<0.05).Conclusions The combined detection of MP⁃Ab and hs⁃CRP in children with early MPP infection can significantly improve the diagnostic sensitivity,accuracy and specificity,reduce the occurrence of missed diagnosis and misdiagnosis,and the predictive value is good.