丙硫氧嘧啶和甲巯咪唑治疗甲亢的效果研究

Study on the therapeutic effect of propylthiouracil and methimazole in the treatment of hyperthyroidism

目的探讨甲状腺功能亢进(甲亢)患者应用丙硫氧嘧啶和甲巯咪唑治疗的临床效果,以期为甲亢的临床治疗提供指导。方法选取2021年6月—2022年9月聊城市茌平区人民医院收治的75例甲亢患者,采用随机数字表法分为对照组37例和观察组38例。对照组实施丙硫氧嘧啶治疗,观察组实施甲巯咪唑治疗。比较两组临床治疗效果、治疗前后甲状腺功能及不良反应发生率。结果观察组治疗总有效率为94.74%,高于对照组的78.38%,差异有统计学意义(χ^(2)=4.341,P<0.05)。治疗后,观察组FT4、FT3水平低于对照组,TSH水平高于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为5.26%,低于对照组的21.62%,差异有统计学意义(χ^(2)=4.341,P<0.05)。结论甲亢患者采用甲巯咪唑治疗的效果优于丙硫氧嘧啶,能明显改善甲状腺功能,且安全性较高,值得临床推广应用。

Objective To explore the clinical efficacy of using propylthiouracil and methimazole in the treatment of hyperthyroidism patients,in order to provide guidance for the clinical treatment of hyperthyroidism.Methods From June 2021 to September 2022,75 hyperthyroidism patients admitted to Liaocheng City Chiping District People's Hospital were selected and divided into control group of 37 cases and observation group of 38 cases,according to random number table method.The control group was treated with propylthiouracil,while the observation group was treated with methimazole.The clinical treatment effects,thyroid function before and after treatment,and incidence of adverse reactions between two groups were compared.Results The total effective rate of treatment in the observation group was 94.74%,which was higher than 78.38%in the control group,and the difference was statistically significant(χ^(2)=4.341,P<0.05).After treatment,the levels of FT4 and FT3 in the observation group were lower than those in the control group,and the levels of TSH were higher than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.26%,which was lower than 21.62%in the control group,and the difference was statistically significant(χ^(2)=4.341,P<0.05).Conclusion The effect of using methimazole to treat hyperthyroidism patients was better than that of propylthiouracil,which could significantly improve thyroid function and had high safety.It was worthy of clinical promotion and application.