人类免疫缺陷病毒/丙型肝炎病毒及人类免疫缺陷病毒/人类疱疹病毒合并感染的流行现状

The epidemic status of HIV/HCV and HIV/HHVs co-infection

在抗逆转录病毒治疗时代,人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者(people livingwithHIV,PLWH)的主要发病及死亡原因是机会性感染。全球现存活的PLWH中,约6.2%的病例合并感染了丙型肝炎病毒(hepatitis C virus,HCV),而几乎所有病例至少合并感染了1种人类疱疹病毒(human herpesvirus,HHV)。因全球检测和治疗覆盖率不足,且受社会经济不平等、医疗资源分配不均和政策限制等的严重影响,HIV的机会性感染已成为全球艾滋病领域最关注的公共卫生问题之一。本文综述了HIV/HCV及HIV/HHVs合并感染的流行现状,并总结了相应的防控策略,以期为防控HIV的机会性感染提供参考。

In the era of antiretroviral therapy,the leading causes of morbidity and mortality among people living with HIV(PLWH)are opportunistic infections.Globally,approximately 6.2%of the surviving PLWH are co-infected with hepatitis C virus(HCV),and nearly all cases are co-infected with at least one type of human herpesvirus(HHV).The detection and treatment coverage worldwide are insufficient and are severely impacted by socioeconomic disparities,uneven distribution of medical resources,and policy constraints.Opportunistic infections in HIV have become one of the most pressing public health issues in the global AIDS field.This article reviews the current prevalence of HIV/HCV and HIV/HHVs co-infections and summarizes the corresponding prevention and control strategies,aiming to provide a reference for the prevention and control of opportunistic infections in HIV.