光动力疗法和手术法治疗口腔白斑的疗效分析

Curative effect analysis of photodynamic therapy and surgical treatment for oral leukoplakia

目的比较光动力疗法和手术法治疗口腔白斑的临床疗效和预后,以期为口腔科医生确定临床诊疗策略提供参考。方法纳入2022年1月—2023年7月在河南省人民医院口腔科就诊且活检确诊为重度异常增生的口腔白斑患者90例,按1∶1的比例随机分为两组,受试组(n=45)采用光动力疗法治疗,对照组(n=45)为传统手术切除方法,随访至术后6个月,以有效率、复发率和患者满意度作为判定疗效标准。结果受试组的有效率(66.7%)和痊愈率(46.7%)均明显高于对照组,差异具有统计学意义(P=0.003 vs.P=0.001);受试组的患者满意度(88.9%)高于对照组(60%),差异具有统计学意义(P=0.002)。结论光动力疗法治疗口腔白斑综合疗效优于传统的手术疗法,值得在临床中推广应用。

Objective To compare the clinical efficacy and prognosis of photodynamic therapy and surgical treatment for oral leukoplakia and to provide a reference for dentists to determine the clinical diagnosis and treatment strategy.Methods Ninety patients diagnosed as severe oral leukoplakia by biopsy in the Department of Stomatology of Henan Provincial People's Hospital from January 2022 to July 2023 were included in the study.They were randomly divided into two groups according to the ratio of 1∶1.The subject group(n=45)was treated with photodynamic therapy,and the control group(n=45)was treated with the traditional surgical excision.Follow-up was conducted for 6 months after the surgery,and the efficacy rate,the recurrence rate and patient satisfaction were used as the criteria for determining the efficacy.Results The effectiveness rate(66.7%)and curative rate(46.7%)of the experimental group were significantly higher than those of the control group,with statistically significant differences(P=0.003 vs.P=0.001).The patient satisfaction rate of the experimental group(88.9%)was higher than that of the control group(60%),with a statistically significant difference(P=0.002).Conclusion The comprehensive therapeutic effect of photodynamic therapy on oral leukoplakia is superior to that of traditional surgical treatment,which is worth promoting in clinical practice.