稳定型冠心病患者中血浆新喋呤水平与患者预后的相关性研究

Correlation between plasma neopterin level and prognosis in patients with stable coronary heart disease

目的探究稳定型冠心病患者中血浆新喋呤(neopterin,NPT)水平与患者预后的相关性。方法回顾性选取联勤保障部队第九八八医院心血管内科2020年6月至2022年6月收治的90例稳定型冠心病患者。按照预后分为预后不良组和预后良好组,分别是30例和60例。观察两组患者的一般资料,包括患者的年龄、性别、吸烟、锻炼、高血压、糖尿病、各项血脂水平、炎症因子指标水平等。并分析患者血清中NPT表达水平与其预后的相关性。结果90例稳定型冠心病患者中预后良好的冠心病患者有60例,预后不良的冠心病患者30例。两组患者在年龄、性别、吸烟、锻炼、高血压、糖尿病、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白(VLDL)以及白介素-8(IL-8)等一般资料的比较中均无明显差异(P>0.05)。预后良好组患者的血清NPT指标水平与预后不良组相比,具有显著差异,P<0.05。采用Spearman分析血清NPT指标水平与稳定型冠心病患者预后之间的关系,发现血清NPT指标水平与稳定型冠心病患者预后呈负相关关系(OR=-0.225;P=0.003)。结论血清NPT指标水平与稳定型冠心病患者预后呈负相关关系,所以在对稳定型冠心病患者进行治疗的过程中,动态监测血清NPT指标水平的变化情况可以为临床预防不良心血管事件的发生提供依据。

Objective To investigate the correlation between plasma neopterin(NPT)level and prognosis in patients with stable coronary heart disease(CHD).Methods Totallty 90 patients with stable coronary heart disease admitted to the cardiovascular department of our hospital from June 2020 to June 2022 were retrospectively selected.According to the prognosis,the patients were divided into the poor prognosis group and the good prognosis group,with 30 and 60 cases respectively.General data of the two groups of patients were observed,including age,gender,smoking,exercise,hypertension,diabetes,blood lipid levels,and inflammatory factor indexes.The correlation between serum NPT expression and prognosis was analyzed.Results Among the 90 patients with stable CHD,60 had good prognosis and 30 had poor prognosis.There were no significant differences in age,sex,smoking,exercise,hypertension,diabetes,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),very low density lipoprotein(VLDL)and interleukin-8(IL-8)between the two groups(P>0.05).The level of serum NPT index in the good prognosis group was significantly different from that in the poor prognosis group(P<0.05).Spearman analysis was used to analyze the relationship between serum NPT index level and prognosis of patients with stable coronary heart disease,and it was found that serum NPT index level was negatively correlated with prognosis of patients with stable coronary heart disease(OR=-0.225;P=0.003).Conclusion Serum NPT index level is negatively correlated with the prognosis of patients with stable coronary heart disease.Therefore,dynamic monitoring of serum NPT index level during the treatment of patients with stable coronary heart disease can provide a basis for clinical prevention of adverse cardiovascular events.