老年重症患者替考拉宁血药浓度影响因素分析

Analysis of factors of teicoplanin concentration in elderly critically ill patients

目的评价老年重症患者替考拉宁血药浓度的影响因素。方法回顾性分析2021年3月至2024年2月北京电力医院接受替考拉宁治疗患者的病理生理数据,采用单因素分析和多元线性回归分析影响替考拉宁谷浓度达标的因素。结果共纳入72例患者,替考拉宁平均谷浓度为(15.1±7.6)μg/mL。多元线性回归结果显示,替考拉宁谷浓度与白蛋白(t=2.262,P=0.027)和负荷剂量(t=2.980,P=0.004)相关。不达标患者替考拉宁血药谷浓度与负荷剂量(t=2.059,P=0.045)相关。结论对于老年重症患者,白蛋白水平和负荷剂量是替考拉宁谷浓度的主要影响因素;谷浓度不达标者,负荷剂量是主要影响因素。

Objective To evaluate the factors influencing the trough concentration of teicoplanin in elderly critically ill patients and to provide a reference for clinical medication.Methods The pathophysiological data of patients treated with teicoplanin were retrospectively collected from March 2021 to February 2024 in Beijing Electric Power Hospital.Univariate analysis and multiple linear regression analysis were used to identify factors influencing the achievement of the target through the concentration of teicoplanin.Results A total of 72 elderly critically ill patients treated with teicoplanin were collected,with an average trough concentration of(15.1±7.6)μg/mL.Multiple linear regression revealed that the trough concentration of teicoplanin was correlated with albumin levels(t=2.262,P=0.027)and loading dose(t=2.980,P=0.004).Among patients who did not achieve the target trough concentration,the trough concentration of teicoplanin was correlated with the loading dose(t=2.059,P<0.05).Conclusion For elderly critically ill patients,albumin levels and loading dose are the primary factors influencing the trough concentration of teicoplanin.Among patients who fail to achieve the target trough concentration,the loading dose is the main influencing factor.In clinical treatment,these factors should be comprehensively considered,and therapeutic drug monitoring should be performed timely to adjust the medication regimen and achieve individualized treatment.