半夏化学成分与药理作用研究进展及其质量标志物(Q-Marker)预测

Research progress on chemical constituents and pharmacological effects of Pinelliae Rhizoma and its quality marker prediction analysis

半夏Pinelliae Rhizoma为常用大宗药材,具有燥湿化痰、降逆止呕、消痞散结的功效,主要含有机酸、生物碱、挥发油、氨基酸、甾醇等多种活性成分,现代研究表明半夏具有镇咳祛痰、镇吐、抗肿瘤、抗炎、抗肥胖、镇静催眠等药理作用。通过梳理其化学成分、药理作用及毒性,对其质量标志物(quality marker,Q-Marker)进行预测分析,结果显示麻黄碱、葫芦巴碱、鸟苷、腺苷、尿苷、肌苷、尿嘧啶、草酸钙、琥珀酸、腺嘌呤等可能作为半夏潜在的Q-Marker,为其药效物质基础及质量控制提供参考。

Banxia(Pinelliae Rhizoma) is commonly used as a bulk herb,it has the effect of drying damp and resolving phlegm,reducing reverse vomiting,eliminating ruffian and dispersing knots,mainly contains organic acids,alkaloids,volatile oil,amino acids,sterols and other active ingredients,modern research shows that Pinelliae Rhizoma has a cough expectorant,antiemetic,antitumor,antiinflammatory,anti-obesity,sedative-hypnotic and other pharmacological effects.By combing its chemical constituents,pharmacological effects and toxicity,the quality marker(Q-Marker) is predicted and analyzed.The results show that ephedrine,trigonelline,guanosine,adenosine,uridine,inosine,uracil,calcium oxalate,succinate acid and adenine,etc.,may be potential QMarkers,providing reference for the pharmacodynamic material basis and quality control of Pinelliae Rhizoma.