靶向嗅觉蛋白的植物精油源潜在昆虫行为控制剂研究进展

Research progress on potential insect behavior control agents originated from plant essential oil targeting olfactory proteins

昆虫具有敏锐且复杂的嗅觉系统,这一系统的运行离不开多种嗅觉蛋白的参与。嗅觉蛋白可以通过对外界气味分子的捕获、运输、识别和降解,进而调控昆虫的取食、交配、繁殖、报警等一系列生理行为。本文综述了昆虫嗅觉蛋白中的气味结合蛋白(OBPs)和嗅觉受体(ORs)在调控昆虫行为上的功能及其晶体结构研究进展,并根据已报道的气味结合蛋白或嗅觉受体与配体小分子的共晶结构,重点分析了二者的互作模式。同时以植物精油为代表,介绍了其在调控昆虫行为活性方面的研究进展,期望为以昆虫气味结合蛋白或嗅觉受体为潜在靶标,聚焦新颖的天然植物精油源先导结构,开发新型的昆虫行为控制剂提供参考。

Insects possess some sensitive and complex olfactory systems,whose operation is inseparable from the participation of a variety of olfactory proteins.These proteins can capture,transport,recognize and degrade external odor molecules,and then regulate a series of physiological behaviors of insects such as feeding,mating,reproduction and alarm.In this paper,the functions and crystal structures of odorant binding proteins(OBPs)and olfactory receptors(ORs)in insect olfactory proteins are reviewed.The interaction modes between odorant binding proteins or olfactory receptors and small ligand molecules were also analyzed according to the reported co-crystal structures.Furthermore,the regulating insect behavior study on the plant essential oils was also summarized in this paper.The review is aimed to provide reference on the development of insect behavior control agents with novel plant essential oil-originated structures as leading ones targeted on insect odorant binding proteins or olfactory receptors.