香豆素类天然产物Murraol和(E)-Suberenol的合成研究

Synthesis of the Natural Coumarin Products Murraol and(E)-Suberenol

目的:一步高效地合成香豆素类天然产物Murraol和(E)-Suberenol,为类似天然产物的合成提供有力支撑。方法:以溴代香豆素为原料,通过过渡金属钯催化的Heck偶联反应合成香豆素类天然产物Murraol和(E)-Suberenol。结果:高效、简捷地完成了2个香豆素类天然产物Murraol和(E)-Suberenol的合成。结论:该合成方法具有操作简单、反应条件温和、符合原子经济性的特点,适用于工业化生产。

Objective:To efficiently synthesize the natural coumarin products Murraol and(E)-Suberenol in a single step,and provide strong support for the synthesis of similar natural products.Methods:Using brominated coumarin as the starting material,the natural coumarin products Murraol and(E)-Suberenol were synthesized by Heck coupling reaction catalyzed by transition metal palladium.Results:The synthesis of both natural coumarin products Murraol and(E)-Suberenol were efficiently and straightforwardly achieved.Conclusion:The synthetic method has the characteristics of simple operation,mild reaction conditions and atomic economy,and is suitable for industrial production.